Human TELO2 cDNA Clone Expression Plasmid – Cat# MBS1277296

TELO2 cDNA Clone – TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) (Human)

Name: TELO2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277296
Price: 940 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277296

MBS1277296 is a cDNA clone targeting TELO2. More details

$940 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TELO2, cDNA Clone

Full Product Name

TELO2 cDNA Clone

Product Gene Name

TELO2 cdna clone

Sequence

atggagccag caccctcaga ggttcgactc gccgtccggg aagccattca tgccctctcg tcttcggagg atggcggcca catcttctgc accctggagt ccctgaagcg gtatctcggt gagatggagc ctccagcgct cccgagggag aaggaggagt ttgcctcggc ccacttctcg cctgtcctca gatgtcttgc cagcaggctg agcccagcct ggctggagct gctgccccat ggccgcctgg aggagctgtg ggccagcttc ttcctggagg gcccggcgga ccaagccttc ctggtgttga tggagaccat cgagggtgct gcgggcccca gcttccggct gatgaagatg gcgcggctgc tggccagatt cctgcgcgag ggccggctgg cagtgctgat ggaggcgcag tgtcggcagc agacgcggcc cggcttcatc ctgctccggg agacgctgct gggcaaggtg gtggccctgc ccgatcacct gggcaaccgc ctgcagcagg agaacttggc cgagttcttc ccccagaact acttccgcct gctcggcgag gaggtcgtcc gggtgctgca ggcggttgtg gactctctcc aaggtggcct ggattcctcc gtgtccttcg tgtctcaggt ccttgggaaa gcctgtgtcc acgggaggca gcaggagatc ctgggcgtgc tggtaccccg gctggcagcg ctcacccagg gcagctacct gcaccagcgc gtctgctggc gcctggtgga gcaagtgccg gaccgggcca tggaggctgt gctgaccggg ctggtggagg ccgcactggg gcctgaggtc ctttcgagac tgctggggaa cctggtggtg aagaacaaga aggcccagtt tgtgatgacc cagaagcttc tgttcttaca gtcccggctc acgacgccca tgctgcagag cctgctgggc catctggcca tggacagcca gcggcgcccg ctcctgctgc aggtgctgaa ggagctgttg gagacgtggg gcagcagcag tgccatccgc cacactcccc tgccgcagca gcgccacgtc agcaaggctg tcctcatctg cctggcgcaa ctcggggagc cggaactgcg ggacagccgg gatgaactgc tggccagcat gatggcgggc gtgaagtgcc gcctggacag tagcctgccc cccgtgcgac gcctgggcat gatcgtggca gaggtcgtta gtgcccggat ccaccccgag gggcctcccc tgaaattcca gtacgaagag gatgaactga gcctcgagct gctggccttg gcctcccccc agcctgcggg tgacggcgcc tcggaggcgg gcacgtccct cgttccagcc acggcagagc cccctgcaga gacccccgca gagatcgtgg atggcggcgt cccccaagca cagctggcgg gctctgactc ggacctggac agcgatgatg agtttgtccc ctacgacatg tcgggggaca gagagctgaa gagcagcaag gctcctgcct acgtccggga ctgcgtggaa gccctgacca cgtctgagga catagagcgc tgggaggcag ccctgcgggc ccttgagggc ctggtctaca ggagccccac agccactcgg gaggtgagcg tggagctggc caaggtgctt ctgcatctgg aggagaagac ctgtgtggtg ggatttgcag ggctgcgcca gagagccctg gtggccgtca cggtcacaga cccggccccg gtggccgact atctgacctc acagttctat gccctcaact acagcctccg gcagcgcatg gacatcctgg atgtgctgac tctggctgcc caggagctgt ctaggcctgg gtgcctcggg aggactcccc aacctggctc cccaagtccc aacaccccgt gcctgccaga ggcagccgtc tctcagcctg gcagtgccgt ggcgtctgac tggcgggtgg tggtggagga gcggatcaga agcaagaccc agcggctctc caagggtggc ccgaggcagg gcccggcagg cagccccagc agattcaact ccgtggccgg ccacttcttc ttccccctcc ttcagcgctt tgacaggcct ctggtgacct tcgacctctt gggagaagac cagctggttc tcggaaggct ggcgcacacc ttaggggccc tgatgtgcct ggctgttaac accacggtgg ctgtggccat gggcaaggcc ctgctggaat tcgtgtgggc ccttcgcttc cacatcgatg cctacgtgcg ccaggggctg ttgtcggccg tctcctccgt cctgctcagc ctgcctgctg cgcgcctgct ggaggacctg atggacgagc tgctggaagc ccggtcctgg ctggcggacg tggctgagaa agacccggac gaggactgca ggacgctggc actgagggcc ctgctgcttc tgcagagact caagaacagg ctcctcccac ccgcgtctcc ctag

Molecular Weight

91,747 Da

OMIM

611140

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TELO2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TELO2. It may not necessarily be applicable to this product.

NCBI GI #

34782786

NCBI GeneID

9894

NCBI Accession #

BC017188

UniProt Secondary Accession #

O75168; Q7LDV4; Q9BR21; D3DU73

UniProt Related Accession #

Q9Y4R8

NCBI Official Full Name

Homo sapiens TEL2, telomere maintenance 2, homolog (S. cerevisiae), mRNA

NCBI Official Synonym Full Names

telomere maintenance 2

NCBI Official Symbol

TELO2

NCBI Official Synonym Symbols

CLK2; TEL2; YHFS

UniProt Protein Name

Telomere length regulation protein TEL2 homolog

UniProt Synonym Protein Names

Protein clk-2 homolog; hCLK2

Protein Family

Telomere length regulation protein

UniProt Gene Name

TELO2

UniProt Synonym Gene Names

KIAA0683; hCLK2

UniProt Entry Name

TELO2_HUMAN

NCBI Protein Information

telomere length regulation protein TEL2 homolog

NCBI Summary for TELO2

This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]

UniProt Comments for TELO2

TELO2: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. Belongs to the TEL2 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; intracellular; nucleus; TORC2 complex

Molecular Function: Hsp90 protein binding; protein binding; protein complex binding; protein kinase binding

Biological Process: protein stabilization; regulation of TOR signaling pathway

Disease: You-hoover-fong Syndrome

Research Articles on TELO2

1. IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TELO2 cdna clone

Products by Pathway	Pathway Diagram
Fanconi Anemia Pathway antibodies	Fanconi Anemia Pathway Diagram
Fanconi Anemia Pathway antibodies	Fanconi Anemia Pathway Diagram

Diseases associated with TELO2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with TELO2 and Neoplasms

Organs/Tissues associated with TELO2 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with TELO2 and Blood