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TFG cDNA Clone – TRK-Fused Gene (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266958

MBS1266958 is a cDNA clone targeting TFG. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TFG, cDNA Clone
Full Product Name
TFG cDNA Clone
Product Gene Name
TFG cdna clone
Sequence
atgaacggac agttggatct aagtgggaag ctaatcatca aagctcaact tggggaggat attcggcgaa ttcctattca taatgaagat attacttatg atgaattagt gctaatgatg caacgagttt tcagaggaaa acttctgagt aatgatgaag taacaataaa gtataaagat gaagatggag atcttataac aatttttgat agttctgacc tttcctttgc aattcagtgc agtaggatac tgaaactgac attatttgtt aatggccagc caagacccct tgaatcaagt caggtgaaat atctccgtcg agaactgata gaacttcgaa ataaagtgaa tcgtttattg gatagcttgg aaccacctgg agaaccagga ccttccacca atattcctga aaatgatact gtggatggta gggaagaaaa gtctgcttct gattcttctg gaaaacagtc tactcaggtt atggcagcaa gtatgtctgc ttttgatcct ttaaaaaacc aagatgaaat caataaaaat gttatgtcag cgtttggctt aacagatgat caggtttcag ggccacccag tgctcctgca gaagatcgtt caggaacacc cgacagcatt gcttcctcct cctcagcagc tcacccacca ggcgttcagc cacagcagcc accatataca ggagctcaga ctcaagcagg tcagattgaa ggtcagatgt accaacagta ccagcaacag gccggctatg gtgcacagca gccgcaggct ccacctcagc agcctcaaca gtatggtatt cagtattcag caagctatag tcagcagact ggacctcaac aacctcagca gttccaggga tatggccagc aaccaacttc ccaggcacca gctcctgcct tttctggtca gcctcaacaa ctgcctgctc agccgccaca gcagtaccag gcgagcaatt atcctgcaca aacttacact gcccaaactt ctcagcctac taattatact gtggctcctg cctctcaacc tggaatggct ccaagccaac ctggggccta tcaaccaaga ccaggtttta cttcacttcc tggaagtacc atgacccctc ctccaagtgg gcctaatcct tatgcgcgta accgtcctcc ctttggtcag ggctataccc aacctggacc tggttatcga taa
Molecular Weight
30,921 Da
OMIM
602498
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TFG cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TFG. It may not necessarily be applicable to this product.

NCBI GI #
33876274
NCBI GeneID
10342
NCBI Accession #
BC001483
UniProt Secondary Accession #
Q15656; Q969I2; D3DN49; G5E9V1; K0J5S8; K0J6K2
UniProt Related Accession #
Q92734
NCBI Official Full Name
Homo sapiens TRK-fused gene, mRNA
NCBI Official Synonym Full Names
TRK-fused gene
NCBI Official Symbol
TFG
NCBI Official Synonym Symbols
TF6; HMSNP; SPG57; TRKT3
UniProt Protein Name
Protein TFG
UniProt Synonym Protein Names
TRK-fused gene protein
Protein Family
Protein
UniProt Gene Name
TFG
UniProt Entry Name
TFG_HUMAN
NCBI Protein Information
protein TFG

NCBI Summary for TFG

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
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UniProt Comments for TFG

TFG: Defects in TFG are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.

Protein type: Oncoprotein; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q12.2

Cellular Component: cytosol

Molecular Function: identical protein binding; protein binding; signal transducer activity

Biological Process: COPII coating of Golgi vesicle; positive regulation of I-kappaB kinase/NF-kappaB cascade

Disease: Neuropathy, Hereditary Motor And Sensory, Okinawa Type; Spastic Paraplegia 57, Autosomal Recessive
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Research Articles on TFG

1. HMSN-P caused by p.Pro285Leu mutation in TFG is not confined to patients with Far East ancestry.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TFG cdna clone

 Products by Pathway  Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram

Diseases associated with TFG cdna clone

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >22 publications with TFG and Necrosis
 Fibrosis Antibodies  >20 publications with TFG and Fibrosis
 Inflammation Antibodies  >13 publications with TFG and Inflammation
 Drug Toxicity Antibodies  >10 publications with TFG and Drug Toxicity
 Liver Diseases Antibodies  >8 publications with TFG and Liver Diseases
 Kidney Diseases Antibodies  >8 publications with TFG and Kidney Diseases
 Brain Diseases Antibodies  >6 publications with TFG and Brain Diseases
 Autoimmune Diseases Antibodies  >5 publications with TFG and Autoimmune Diseases
 Kidney Neoplasms Antibodies  >4 publications with TFG and Kidney Neoplasms
 Hyperplasia Antibodies  >3 publications with TFG and Hyperplasia

Organs/Tissues associated with TFG cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with TFG and Blood
 Lung Antibodies  >26 publications with TFG and Lung
 Bone Antibodies  >21 publications with TFG and Bone
 Heart Antibodies  >20 publications with TFG and Heart
 Muscle Antibodies  >18 publications with TFG and Muscle
 Thyroid Antibodies  >17 publications with TFG and Thyroid
 Liver Antibodies  >15 publications with TFG and Liver
 Kidney Antibodies  >14 publications with TFG and Kidney
 Lymph Node Antibodies  >14 publications with TFG and Lymph Node
 Vascular Antibodies  >14 publications with TFG and Vascular
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