Human TP53BP2 cDNA Clone Expression Plasmid – Cat# MBS1278986

TP53BP2 cDNA Clone – Tumor Protein P53 Binding Protein, 2 (Human)

Name: TP53BP2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1278986
Price: 1315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278986

MBS1278986 is a cDNA clone targeting TP53BP2. More details

$1315 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TP53BP2, cDNA Clone

Full Product Name

TP53BP2 cDNA Clone

Product Gene Name

TP53BP2 cdna clone

Sequence

ATGAACGCCC CCCTGGCAGG GACATTGGTA GTGAGTGGAC CAAGATCTCA GGATCCAAGT TTAAAAAGAA ATGGTGTAAA AGTTCCTGGT GAATATCGAA GAAAGGAGAA CGGTGTTAAT AGTCCTAGGA TGGATCTGAC TCTTGCTGAA CTTCAGGAAA TGGCATCTCG CCAGCAGCAA CAGATTGAAG CCCAGCAACA ATTGCTGGCA ACTAAGGAAC AGCGCTTAAA GTTTTTGAAA CAACAAGATC AGCGACAACA GCAACAAGTT GCTGAGCAGG AGAAACTTAA AAGGCTAAAA GAAATAGCTG AGAATCAGGA AGCTAAGCTA AAAAAAGTGA GAGCACTTAA AGGCCACGTG GAACAGAAGA GACTAAGCAA TGGGAAACTT GTGGAGGAAA TTGAACAGAT GAATAATTTG TTCCAGCAAA AACAGAGGGA GCTCGTCCTG GCTGTGTCAA AAGTAGAAGA ACTGACCAGG CAGCTAGAGA TGCTCAAGAA CGGCAGGATC GACAGCCACC ATGACAATCA GTCTGCAGTG GCTGAGCTTG ATCGCCTCTA TAAGGAGCTG CAGCTAAGAA ACAAATTGAA TCAAGAGCAG AATGCCAAGC TACAACAACA GAGGGAGTGT TTGAATAAGC GTAATTCAGA AGTGGCAGTC ATGGATAAGC GTGTTAATGA GCTGAGGGAC CGGCTGTGGA AGAAGAAGGC AGCTCTACAG CAAAAAGAAA ATCTACCAGT TTCATCTGAT GGAAATCTTC CCCAGCAAGC CGCGTCAGCC CCAAGCCGTG TGGCTGCAGT AGGTCCCTAT ATCCAGTCGT CTACTATGCC TCGGATGCCC TCAAGGCCTG AATTGCTGGT GAAGCCAGCC CTGCCGGATG GTTCCTTGGT CATTCAGGCT TCAGAGGGGC CGATGAAAAT ACAGACACTG CCCAACATGA GATCTGGGGC TGCTTCACAA ACTAAAGGCT CTAAAATCCA TCCAGTTGGC CCTGATTGGA GTCCTTCAAA TGCAGATCTT TTCCCAAGCC AAGGCTCTGC TTCTGTACCT CAAAGCACTG GGAATGCTCT GGATCAAGTT GATGATGGAG AGGTTCCGCT GAGGGAGAAA GAGAAGAAAG TGCGTCCGTT CTCAATGTTT GATGCAGTAG ACCAGTCCAA TGCCCCACCT TCCTTTGGTA CTCTGAGGAA GAACCAGAGC AGTGAAGATA TCTTGCGGGA TGCTCAGGTT GCAAATAAAA ATGTGGCTAA AGTACCACCT CCTGTTCCTA CAAAACCAAA ACAGATTAAT TTGCCTTATT TTGGACAAAC TAATCAGCCA CCTTCAGACA TTAAGCCAGA CGGAAGTTCT CAGCAGTTGT CAACAGTTGT TCCGTCCATG GGAACTAAAC CAAAACCAGC AGGGCAGCAG CCGAGAGTGC TGCTATCTCC CAGCATACCT TCGGTTGGCC AAGACCAGAC CCTTTCTCCA GGTTCTAAGC AAGAAAGTCC ACCTGCTGCT GCCGTCCGGC CCTTTACTCC CCAGCCTTCC AAAGACACCT TACTTCCACC CTTCAGAAAA CCCCAGACCG TGGCAGCAAG TTCAATATAT TCCATGTATA CGCAACAGCA GGCGCCAGGA AAAAACTTCC AGCAGGCTGT GCAGAGCGCG TTGACCAAGA CTCATACCAG AGGGCCACAC TTTTCAAGTG TATATGGTAA GCCTGTAATT GCTGCTGCCC AGAATCAACA GCAGCACCCA GAGAACATTT ATTCCAATAG CCAGGGCAAG CCTGGCAGTC CAGAACCTGA AACAGAGCCT GTTTCTTCAG TTCAGGAGAA CCATGAAAAC GAAAGAATTC CTCGGCCACT CAGCCCAACT AAATTACTGC CTTTCTTATC TAATCCTTAC CGAAACCAGA GTGATGCTGA CCTAGAAGCC TTACGAAAGA AACTGTCTAA CGCACCAAGG CCTCTAAAGA AACGTAGTTC TATTACAGAG CCAGAGGGTC CTAATGGGCC AAATATTCAG AAGCTTTTAT ATCAGAGGAC CACCATAGCG GCCATGGAGA CCATCTCTGT CCCATCATAC CCATCCAAGT CAGCTTCTGT GACTGCCAGC TCAGAAAGCC CAGTAGAAAT CCAGAATCCA TATTTACATG TGGAGCCCGA AAAGGAGGTG GTCTCTCTGG TTCCTGAATC ATTGTCCCCA GAGGATGTGG GGAATGCCAG TACAGAGAAC AGTGACATGC CAGCTCCTTC TCCAGGCCTT GATTATGAGC CTGAGGGAGT CCCAGACAAC AGCCCAAATC TCCAGAATAA CCCAGAAGAA CCAAATCCAG AGGCTCCACA TGTGCTTGAT GTGTACCTGG AGGAGTACCC TCCATACCCA CCCCCACCAT ACCCATCTGG GGAGCCTGAA GGGCCCGGAG AAGACTCGGT GAGCATGCGC CCGCCTGAAA TCACCGGGCA GGTCTCTCTG CCTCCTGGTA AAAGGACAAA CTTGCGTAAA ACTGGCTCAG AGCGTATCGC TCATGGAATG AGGGTGAAAT TCAACCCCCT TGCTTTACTG CTAGATTCGT CTTTGGAGGG AGAATTTGAC CTTGTACAGA GAATTATTTA TGAGGTTGAT GACCCAAGCC TCCCCAATGA TGAAGGCATC ACGGCTCTTC ACAATGCTGT GTGTGCAGGC CACACAGAAA TCGTTAAGTT CCTGGTACAG TTTGGTGTAA ATGTAAATGC TGCTGATAGT GATGGATGGA CTCCATTACA TTGTGCTGCC TCATGTAACA ACGTCCAAGT GTGTAAGTTT TTGGTGGAGT CAGGAGCCGC TGTGTTTGCC ATGACCTACA GTGACATGCA GACTGCTGCA GATAAGTGCG AGGAAATGGA GGAAGGCTAC ACTCAGTGCT CCCAATTTCT TTATGGAGTT CAGGAGAAGA TGGGCATAAT GAATAAAGGA GTCATTTATG CGCTTTGGGA TTATGAACCT CAGAATGATG ATGAGCTGCC CATGAAAGAA GGAGACTGCA TGACAATCAT CCACAGGGAA GACGAAGATG AAATCGAATG GTGGTGGGCG CGCCTTAATG ATAAGGAGGG ATATGTTCCA CGTAACTTGC TGGGACTGTA CCCAAGAATT AAACCAAGAC AAAGGAGCTT GGCCTGA

Molecular Weight

126,323 Da

OMIM

602143

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TP53BP2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TP53BP2. It may not necessarily be applicable to this product.

NCBI GI #

25955664

NCBI GeneID

7159

NCBI Accession #

BC040247

UniProt Secondary Accession #

Q12892; Q86X75; Q96KQ3; B4DG66

UniProt Related Accession #

Q13625

NCBI Official Full Name

Homo sapiens tumor protein p53 binding protein, 2, mRNA

NCBI Official Synonym Full Names

tumor protein p53 binding protein 2

NCBI Official Symbol

TP53BP2

NCBI Official Synonym Symbols

BBP; 53BP2; ASPP2; P53BP2; PPP1R13A

UniProt Protein Name

Apoptosis-stimulating of p53 protein 2

UniProt Synonym Protein Names

Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2

Protein Family

Apoptosis-stimulating of p53 protein

UniProt Gene Name

TP53BP2

UniProt Synonym Gene Names

ASPP2; BBP; Bbp; 53BP2; p53-binding protein 2; p53BP2

UniProt Entry Name

ASPP2_HUMAN

NCBI Protein Information

apoptosis-stimulating of p53 protein 2

NCBI Summary for TP53BP2

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for TP53BP2

53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3/SH2 adaptor activity

Biological Process: negative regulation of cell cycle; regulation of apoptosis; signal transduction

Research Articles on TP53BP2

1. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TP53BP2 cdna clone

Products by Pathway	Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram

Diseases associated with TP53BP2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>39 publications with TP53BP2 and Neoplasms
Necrosis Antibodies	>6 publications with TP53BP2 and Necrosis
Nervous System Diseases Antibodies	>6 publications with TP53BP2 and Nervous System Diseases
Brain Diseases Antibodies	>5 publications with TP53BP2 and Brain Diseases
Nerve Degeneration Antibodies	>3 publications with TP53BP2 and Nerve Degeneration
Cell Transformation, Neoplastic Antibodies	>3 publications with TP53BP2 and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>2 publications with TP53BP2 and Liver Diseases
Drug Toxicity Antibodies	>2 publications with TP53BP2 and Drug Toxicity
Inflammation Antibodies	>2 publications with TP53BP2 and Inflammation
Pancreatic Neoplasms Antibodies	>2 publications with TP53BP2 and Pancreatic Neoplasms

Organs/Tissues associated with TP53BP2 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>11 publications with TP53BP2 and Brain
Lung Antibodies	>8 publications with TP53BP2 and Lung
Lymph Node Antibodies	>5 publications with TP53BP2 and Lymph Node
Kidney Antibodies	>4 publications with TP53BP2 and Kidney
Stomach Antibodies	>4 publications with TP53BP2 and Stomach
Liver Antibodies	>4 publications with TP53BP2 and Liver
Blood Antibodies	>3 publications with TP53BP2 and Blood
Prostate Antibodies	>3 publications with TP53BP2 and Prostate
Bone Antibodies	>2 publications with TP53BP2 and Bone
Heart Antibodies	>2 publications with TP53BP2 and Heart