AURKC Immunizing Blocking Peptide

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.

Protein type: Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; cytoplasm; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: ATP binding; histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: attachment of spindle microtubules to kinetochore; cytokinesis; histone modification; meiotic cell cycle; oocyte development; positive regulation of cytokinesis; protein amino acid phosphorylation; spermatogenesis; spindle midzone assembly involved in mitosis

Disease: Spermatogenic Failure 5