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GFR alpha-1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS855455

MBS855455 is an antibody targeting GFR alpha-1. Also known as GFR alpha-1 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GFR alpha-1, Antibody
Full Product Name
GFR alpha-1 Antibody
Product Gene Name
Product Synonym Names
GDNFRA; GFR-ALPHA-1; MGC23045; RET1L; RETL1; TRNR1; GDNF FAMILY RECEPTOR ALPHA-1; GDNF family receptor alpha 1 isoform a preproprotein; GDNF family receptor alpha 1 isoform b preproprotein; GPI-linked anchor protein; Glial cell line-derived neurotrophic factor receptor alpha; PI-linked cell-surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
GFR alpha-1 antibody detects endogenous levels of total GFR alpha-1 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
50,838 Da
OMIM
601496
3D Structure
ModBase 3D Structure for P56159
Immunogen
The antiserum was produced against synthesized peptide derived from human GFR alpha-1.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GFR alpha-1 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-GFR alpha-1 antibody
IHC: 1:50-1:100
ELISA: 1:1000

Immunohistochemistry (IHC) of anti-GFR alpha-1 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue, using GFR alpha-1 antibody.
Anti-GFR alpha-1 Antibody – Cat# MBS855455

Product References and Citations for anti-GFR alpha-1 antibody

Alice J. Sigurdson, AACR Meeting Abstracts, Mar 2004; 2004: 343. S Borrego, J. Med. Genet., Mar 2003; 40: 18. Anna Popsueva, J. Cell Biol., Apr 2003; 161: 119. A. Garcès, J. Neurosci., Jul 2000; 20: 4992.

Other Notes

Small volumes of anti-GFR alpha-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GFR alpha-1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
GDNF family receptor alpha-1 isoform b
NCBI Official Synonym Full Names
GDNF family receptor alpha 1
NCBI Official Symbol
GFRA1
NCBI Official Synonym Symbols
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
UniProt Protein Name
GDNF family receptor alpha-1
UniProt Synonym Protein Names
RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
Protein Family
UniProt Gene Name
GFRA1
UniProt Synonym Gene Names
GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1
NCBI Protein Information
GDNF family receptor alpha-1

NCBI Summary for GFR alpha-1

This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
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UniProt Comments for GFR alpha-1

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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