Rabbit Anti-MCM7 Antibody – Cat# MBS8501990

MCM7 Antibody – Rabbit

Name: MCM7 Antibody; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8501990
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8501990

The minichromosome maintenance (MCM) 2-7 proteins are a family of six related proteins required for the initiation and elongation of DNA replication. MCM2-7 bind together to form the heterohexameric MCM complex that is thought to act as a replicative helicase… More details

$400 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCM7, Antibody

Full Product Name

MCM7 Antibody

Product Gene Name

anti-MCM7 antibody

Product Synonym Names

MCM7; CDABP0042; CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS-146

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity purification

Preparation and Storage

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

Molecular Weight

81kDa

OMIM

600592

3D Structure

ModBase 3D Structure for P33993

Immunogen

Recombinant protein of human MCM7

Storage Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-MCM7 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-MCM7 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-MCM7 antibody

WB: 1:500-1:2000
IHC: 1:50-1:200

Product References and Citations for anti-MCM7 antibody

1. Lei, M. and Tye, B.K. (2001) J Cell Sci 114, 1447-54. 2. Lygerou, Z. and Nurse, P. (2000) Science 290, 2271-3. 3. Forsburg, S.L. (2004) MicrobiolMolBiol Rev 68, 109-31. 4. Tye, B.K. and Sawyer, S. (2000) J BiolChem 275, 34833-6. 5. Labib, K. et al. (2000) Science 288, 1643-7. 6. Charych, D.H. et al. (2008) J Cell Biochem 104, 1075-86. 7. Masai, H. et al. (2006) J BiolChem 281, 39249-61. 8. Lin, D.I. et al. (2008) ProcNatlAcadSci USA 105, 8079-84. 9. Bailis, J.M. et al. (2008) Mol Cell Biol 28, 1724-38.

Other Notes

Small volumes of anti-MCM7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCM7 purchase

MBS8501990 is an antibody targeting MCM7. Also known as MCM7 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM7. It may not necessarily be applicable to this product.

NCBI GI #

518830597

NCBI GeneID

4176

NCBI Accession #

NP_001265524.1

UniProt Primary Accession #

P33993

UniProt Secondary Accession #

Q15076; Q96D34; Q96GL1; A4D2A1; A4D2A2; E9PGN9

UniProt Related Accession #

P33993

GenBank Nucleotide #

NM_001278595.1

NCBI Official Full Name

DNA replication licensing factor MCM7 isoform 2

NCBI Official Synonym Full Names

minichromosome maintenance complex component 7

NCBI Official Symbol

MCM7

NCBI Official Synonym Symbols

MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3

UniProt Protein Name

DNA replication licensing factor MCM7

UniProt Synonym Protein Names

CDC47 homolog; P1.1-MCM3

Protein Family

DNA replication licensing factor

UniProt Gene Name

MCM7

UniProt Synonym Gene Names

CDC47; MCM2

NCBI Protein Information

DNA replication licensing factor MCM7

NCBI Summary for MCM7

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for MCM7

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Research Articles on MCM7

1. High expression of MCM-7 was reduced in BVP-treated cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCM7 antibody

Reference Product	PubMed Publications
MCM2 antibody	>100 publications with MCM7 and MCM2
MCM6 antibody	>53 publications with MCM7 and MCM6
MCM4 antibody	>47 publications with MCM7 and MCM4
MCM3 antibody	>40 publications with MCM7 and MCM3
CDC45 antibody	>33 publications with MCM7 and CDC45
MCM5 antibody	>32 publications with MCM7 and MCM5
CDC6 antibody	>31 publications with MCM7 and CDC6
CDC7 antibody	>9 publications with MCM7 and CDC7
DBF4 antibody	>6 publications with MCM7 and DBF4

Pathways associated with anti-MCM7 antibody

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram

Diseases associated with anti-MCM7 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>109 publications with MCM7 and Neoplasms
Carcinoma Antibodies	>51 publications with MCM7 and Carcinoma
Adenocarcinoma Antibodies	>26 publications with MCM7 and Adenocarcinoma
Prostatic Neoplasms Antibodies	>17 publications with MCM7 and Prostatic Neoplasms
Breast Neoplasms Antibodies	>12 publications with MCM7 and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>12 publications with MCM7 and Carcinoma, Squamous Cell
Disease Models, Animal Antibodies	>10 publications with MCM7 and Disease Models, Animal
Lung Neoplasms Antibodies	>10 publications with MCM7 and Lung Neoplasms
Uterine Cervical Neoplasms Antibodies	>9 publications with MCM7 and Uterine Cervical Neoplasms
Cell Transformation, Neoplastic Antibodies	>8 publications with MCM7 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-MCM7 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>21 publications with MCM7 and Prostate
Lung Antibodies	>15 publications with MCM7 and Lung
Skin Antibodies	>13 publications with MCM7 and Skin
Vascular Antibodies	>12 publications with MCM7 and Vascular
Blood Antibodies	>11 publications with MCM7 and Blood
Liver Antibodies	>9 publications with MCM7 and Liver
Muscle Antibodies	>9 publications with MCM7 and Muscle
Placenta Antibodies	>8 publications with MCM7 and Placenta
Uterus Antibodies	>8 publications with MCM7 and Uterus
Brain Antibodies	>8 publications with MCM7 and Brain