Ret ELISA Kit for Human, Mouse, Rat

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

Ret: a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ret family; TK group

Chromosomal Location of Human Ortholog: 10q11.21

Cellular Component: axon; cell soma; cytosol; dendrite; early endosome; endosome membrane; integral component of plasma membrane; intracellular membrane-bound organelle; membrane raft; plasma membrane; plasma membrane protein complex; receptor complex

Molecular Function: ATP binding; calcium ion binding; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: axon guidance; cellular response to retinoic acid; embryonic epithelial tube formation; enteric nervous system development; homophilic cell adhesion; MAPK cascade; membrane protein proteolysis; neural crest cell migration; neuron adhesion; neuron maturation; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell size; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of metanephric glomerulus development; positive regulation of neuron maturation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of transcription, DNA-templated; posterior midgut development; protein amino acid phosphorylation; regulation of axonogenesis; regulation of cell adhesion; regulation of molecular function; response to drug; response to pain; retina development in camera-type eye; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development

Disease: Hirschsprung Disease, Susceptibility To, 1; Multiple Endocrine Neoplasia, Type Iia; Multiple Endocrine Neoplasia, Type Iib; Thyroid Carcinoma, Familial Medullary; Thyroid Carcinoma, Papillary