AKAP6 siRNA – A-Kinase Anchor Protein 6 (Human)

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]

AKAP6: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: nuclear membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; T-tubule; nuclear envelope; caveola

Molecular Function: protein binding; protein anchor; protein kinase A binding; protein complex scaffold; adenylate cyclase binding

Biological Process: regulation of action potential; cAMP-mediated signaling; negative regulation of cAMP biosynthetic process; positive regulation of NFAT protein import into nucleus; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cell growth; positive regulation of protein phosphatase type 2B activity; protein targeting