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CCL3L1 siRNA – C-C Motif Chemokine 3-Like 1 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8216455

MBS8216455 is an siRNA targeting CCL3L1. Also known as CCL3L1 siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit CCL3L1 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL3L1, siRNA
Full Product Name
CCL3L1 siRNA (Human)
Product Gene Name
CCL3L1 sirna
Product Synonym Names
D17S1718; G0S19-2; SCYA3L1; C-C motif chemokine 3-like 1; G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta protein
Host
Synthetic
Species Reactivity
Human
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
CCL3L1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
10,161 Da
OMIM
601395
3D Structure
ModBase 3D Structure for P16619
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human CCL3L1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for CCL3L1 sirna
RNA Interference (RNAi)

Other Notes

Small volumes of CCL3L1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL3L1. It may not necessarily be applicable to this product.

NCBI GI #
93589094
NCBI GeneID
414062
NCBI Accession #
NP_001001437.2
UniProt Primary Accession #
P16619
UniProt Secondary Accession #
Q3B7A8; Q53YA5; Q96I68; A6NGK6; B2RUX4
UniProt Related Accession #
P16619
GenBank Nucleotide #
NM_001001437.3
NCBI Official Full Name
C-C motif chemokine 3-like 1
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 3-like 3
NCBI Official Symbol
CCL3L3
NCBI Official Synonym Symbols
LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA
UniProt Protein Name
C-C motif chemokine 3-like 1
UniProt Synonym Protein Names
G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta protein
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL3L1
UniProt Synonym Gene Names
D17S1718; G0S19-2; SCYA3L1
UniProt Entry Name
CL3L1_HUMAN
NCBI Protein Information
C-C motif chemokine 3-like 1

NCBI Summary for CCL3L1

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]
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UniProt Comments for CCL3L1

CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: negative regulation of cell proliferation; immune response; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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Research Articles on CCL3L1

1. severe periodontal tissue destruction in Papillon-Lefevre syndrome may be related to excess accumulation of LD78beta and LD78alpha and dysregulation of the microbial-induced inflammatory response in the periodontium

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL3L1 sirna

 Reference Product  PubMed Publications
 CCL4L1 sirna  >2 publications with CCL3L1 and CCL4L1
 CCL4 sirna  >2 publications with CCL3L1 and CCL4
 IL8 sirna  >1 publications with CCL3L1 and IL8
 CCL20 sirna  >1 publications with CCL3L1 and CCL20

Pathways associated with CCL3L1 sirna

 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with CCL3L1 sirna

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1 publications with CCL3L1 and Cardiovascular Diseases
 Myocardial Infarction Antibodies  >1 publications with CCL3L1 and Myocardial Infarction

Organs/Tissues associated with CCL3L1 sirna

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with CCL3L1 and Bone
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