CDK11A siRNA – Cyclin-Dependent Kinase 11a Isoform 1 (Human)

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CDK11A: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, CMGC; Kinase, protein; Cell cycle regulation; EC 2.7.11.22; RNA processing; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; CMGC group; CDK family; PITSLRE subfamily

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity

Biological Process: mitosis; regulation of transcription, DNA-dependent; apoptosis; regulation of cell cycle; regulation of cell growth; protein amino acid phosphorylation; regulation of mRNA processing