CLDND1 siRNA – Claudin Domain-Containing Protein 1 Isoform a (Human)

Name: CLDND1 siRNA; Human; MyBioSource
Brand: MyBioSource
SKU: MBS8205882
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8205882

MBS8205882 is an siRNA targeting CLDND1. Also known as CLDND1 siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit CLDND1 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CLDND1, siRNA

Full Product Name

CLDND1 siRNA (Human)

Product Gene Name

CLDND1 sirna

Product Synonym Names

C3orf4; Claudin domain-containing protein 1; Membrane protein GENX-3745

Host

Synthetic

Species Reactivity

Human

Form/Format

Lyophilized powder

Purity/Purification

> 97%

Specificity

CLDND1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Molecular Weight

17,464 Da

3D Structure

ModBase 3D Structure for Q9NY35

Negative Control

siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.

Quality Control

Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.

Directions for Use

We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).

Components

We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human CLDND1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

Applications Tested/Suitable for CLDND1 sirna

RNA Interference (RNAi)

Other Notes

Small volumes of CLDND1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CLDND1. It may not necessarily be applicable to this product.

NCBI GI #

93588614

NCBI GeneID

56650

NCBI Accession #

NP_001035271.1

UniProt Primary Accession #

Q9NY35

UniProt Secondary Accession #

Q502Y8; Q6UVX2; Q9BUZ9; Q9NZZ5; Q9Y4S9; B3KQR1; D3DN36; F2Z2D9

UniProt Related Accession #

Q9NY35

GenBank Nucleotide #

NM_001040181.1

NCBI Official Full Name

claudin domain-containing protein 1 isoform a

NCBI Official Synonym Full Names

claudin domain containing 1

NCBI Official Symbol

CLDND1

NCBI Official Synonym Symbols

C3orf4; GENX-3745

UniProt Protein Name

Claudin domain-containing protein 1

UniProt Synonym Protein Names

Membrane protein GENX-3745

Protein Family

Claudin domain-containing protein

UniProt Gene Name

CLDND1

UniProt Synonym Gene Names

C3orf4

UniProt Entry Name

CLDN1_HUMAN

NCBI Protein Information

claudin domain-containing protein 1

UniProt Comments for CLDND1

CLDND1: Belongs to the PMP-22/EMP/MP20 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q12.1

Cellular Component: cell surface; apical plasma membrane; integral to membrane

Research Articles on CLDND1

1. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CLDND1 sirna

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with CLDND1 and Inflammation

Organs/Tissues associated with CLDND1 sirna

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>3 publications with CLDND1 and Nerve
Blood Antibodies	>2 publications with CLDND1 and Blood
Spinal Cord Antibodies	>1 publications with CLDND1 and Spinal Cord
Brain Antibodies	>1 publications with CLDND1 and Brain