INHA siRNA – Inhibin Alpha Chain Preproprotein (Human)

Name: INHA siRNA; Inhibin Alpha Chain Preproprotein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS8208810
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8208810

MBS8208810 is an siRNA targeting INHA. Also known as INHA siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit INHA expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

INHA, siRNA

Full Product Name

INHA siRNA (Human)

Product Gene Name

INHA sirna

Product Synonym Names

Inhibin alpha chain

Host

Synthetic

Species Reactivity

Human

Form/Format

Lyophilized powder

Purity/Purification

> 97%

Specificity

INHA siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Molecular Weight

39,670 Da

OMIM

147380

3D Structure

ModBase 3D Structure for P05111

Negative Control

siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.

Quality Control

Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.

Directions for Use

We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).

Components

We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human INHA gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

Applications Tested/Suitable for INHA sirna

RNA Interference (RNAi)

Other Notes

Small volumes of INHA sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for INHA. It may not necessarily be applicable to this product.

NCBI GI #

4504697

NCBI GeneID

3623

NCBI Accession #

NP_002182.1

UniProt Primary Accession #

P05111

UniProt Secondary Accession #

A8K8H5

UniProt Related Accession #

P05111

GenBank Nucleotide #

NM_002191.3

NCBI Official Full Name

inhibin alpha chain preproprotein

NCBI Official Synonym Full Names

inhibin, alpha

NCBI Official Symbol

INHA

UniProt Protein Name

Inhibin alpha chain

Protein Family

Inhibin

UniProt Gene Name

INHA

UniProt Entry Name

INHA_HUMAN

NCBI Protein Information

inhibin alpha chain

NCBI Summary for INHA

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

UniProt Comments for INHA

INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cell soma; extracellular region

Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: negative regulation of B cell differentiation; hemoglobin biosynthetic process; nervous system development; regulation of cell cycle; male gonad development; signal transduction; negative regulation of interferon-gamma biosynthetic process; regulation of cell proliferation; negative regulation of follicle-stimulating hormone secretion; negative regulation of cell cycle; regulation of apoptosis; response to external stimulus; cell surface receptor linked signal transduction; negative regulation of macrophage differentiation; cell-cell signaling; ovarian follicle development; regulation of MAPKKK cascade; negative regulation of phosphorylation; erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell cycle arrest; skeletal development; cell development

Research Articles on INHA

1. Inhibin alpha gene expression in human trophoblasts is regulated by interactions between TFAP2 and cAMP signaling pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with INHA sirna

Reference Product	PubMed Publications
INHBA sirna	>19 publications with INHA and INHBA
INHBB sirna	>19 publications with INHA and INHBB
CGA sirna	>9 publications with INHA and CGA
FST sirna	>6 publications with INHA and FST
FSHB sirna	>4 publications with INHA and FSHB
TGFBR3 sirna	>3 publications with INHA and TGFBR3
ACVR2A sirna	>2 publications with INHA and ACVR2A
INHBE sirna	>1 publications with INHA and INHBE
INHBC sirna	>1 publications with INHA and INHBC

Pathways associated with INHA sirna

Products by Pathway	Pathway Diagram
Glycoprotein Hormones Pathway antibodies	Glycoprotein Hormones Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Ovarian Infertility Genes Pathway antibodies	Ovarian Infertility Genes Pathway Diagram
Peptide Hormone Biosynthesis Pathway antibodies	Peptide Hormone Biosynthesis Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram

Diseases associated with INHA sirna

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>250 publications with INHA and Nervous System Diseases
Pain Antibodies	>159 publications with INHA and Pain
Disease Models, Animal Antibodies	>106 publications with INHA and Disease Models, Animal
Mental Disorders Antibodies	>96 publications with INHA and Mental Disorders
Diabetes Mellitus Antibodies	>80 publications with INHA and Diabetes Mellitus
Necrosis Antibodies	>69 publications with INHA and Necrosis
Heart Diseases Antibodies	>68 publications with INHA and Heart Diseases
Liver Diseases Antibodies	>65 publications with INHA and Liver Diseases
Hypertension Antibodies	>63 publications with INHA and Hypertension
Genital Diseases, Male Antibodies	>58 publications with INHA and Genital Diseases, Male

Organs/Tissues associated with INHA sirna

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>208 publications with INHA and Brain
Lung Antibodies	>135 publications with INHA and Lung
Liver Antibodies	>130 publications with INHA and Liver
Eye Antibodies	>76 publications with INHA and Eye
Ovary Antibodies	>43 publications with INHA and Ovary
Thyroid Antibodies	>26 publications with INHA and Thyroid
Testis Antibodies	>18 publications with INHA and Testis
Uterus Antibodies	>8 publications with INHA and Uterus
Placenta Antibodies	>7 publications with INHA and Placenta