ITPR3 siRNA – Inositol 1,4,5-Trisphosphate Receptor Type 3 (Human)

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; nucleoplasm; membrane; cell soma; apical part of cell; cytoplasm; nucleolus; plasma membrane; myelin sheath; receptor complex; brush border

Molecular Function: protein binding; inositol 1,3,4,5 tetrakisphosphate binding; inositol hexakisphosphate binding; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; sensory perception of umami taste; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; sensory perception of sweet taste; nerve growth factor receptor signaling pathway; protein heterooligomerization; signal transduction; memory; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; phospholipase C activation; energy reserve metabolic process; innate immune response; sensory perception of bitter taste; vascular endothelial growth factor receptor signaling pathway; response to calcium ion; blood coagulation; regulation of insulin secretion; protein homooligomerization

Disease: Diabetes Mellitus, Insulin-dependent