KAT6A siRNA – Histone Acetyltransferase KAT6A Isoform 1 (Human)

This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

MYST3: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. Belongs to the MYST (SAS/MOZ) family.

Protein type: Oncoprotein; Nucleolus; EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 8p11

Cellular Component: nucleoplasm; Golgi apparatus; PML body; nucleolus; nucleosome; nucleus

Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; zinc ion binding; transcription coactivator activity; acetyltransferase activity; chromatin binding; transcription factor binding

Biological Process: heart morphogenesis; nucleosome assembly; establishment and/or maintenance of chromatin architecture; protein amino acid acetylation; transcription, DNA-dependent; embryonic hemopoiesis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; myeloid cell differentiation; histone acetylation; negative regulation of transcription, DNA-dependent; DNA packaging

Disease: Mental Retardation, Autosomal Dominant 32