MS4A3 siRNA – Membrane-Spanning 4-Domains Subfamily A Member 3 Isoform C (Human)

Name: MS4A3 siRNA; Human; MyBioSource
Brand: MyBioSource
SKU: MBS8218308
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8218308

MBS8218308 is an siRNA targeting MS4A3. Also known as MS4A3 siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit MS4A3 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MS4A3, siRNA

Full Product Name

MS4A3 siRNA (Human)

Product Gene Name

MS4A3 sirna

Product Synonym Names

CD20L; HTM4; Membrane-spanning 4-domains subfamily A member 3; CD20 antigen-like protein; Hematopoietic-specific transmembrane protein 4; HTm4

Host

Synthetic

Species Reactivity

Human

Form/Format

Lyophilized powder

Purity/Purification

> 97%

Specificity

MS4A3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Molecular Weight

9,625 Da

OMIM

606498

3D Structure

ModBase 3D Structure for Q96HJ5

Negative Control

siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.

Quality Control

Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.

Directions for Use

We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).

Components

We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human MS4A3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

Applications Tested/Suitable for MS4A3 sirna

RNA Interference (RNAi)

Other Notes

Small volumes of MS4A3 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MS4A3. It may not necessarily be applicable to this product.

NCBI GI #

73486651

NCBI GeneID

932

NCBI Accession #

NP_001026836.1

UniProt Primary Accession #

Q96HJ5

UniProt Secondary Accession #

Q8NHW2; A8MTP8

UniProt Related Accession #

Q96HJ5

GenBank Nucleotide #

NM_001031666.1

NCBI Official Full Name

membrane-spanning 4-domains subfamily A member 3 isoform c

NCBI Official Synonym Full Names

membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)

NCBI Official Symbol

MS4A3

NCBI Official Synonym Symbols

HTM4; CD20L

UniProt Protein Name

Membrane-spanning 4-domains subfamily A member 3

UniProt Synonym Protein Names

CD20 antigen-like protein; Hematopoietic-specific transmembrane protein 4; HTm4

Protein Family

Membrane-spanning 4-domains subfamily

UniProt Gene Name

MS4A3

UniProt Synonym Gene Names

CD20L; HTM4; HTm4

UniProt Entry Name

MS4A3_HUMAN

NCBI Protein Information

membrane-spanning 4-domains subfamily A member 3

NCBI Summary for MS4A3

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

UniProt Comments for MS4A3

MS4A3: Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP). Belongs to the MS4A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: perinuclear region of cytoplasm; integral to membrane; endomembrane system

Molecular Function: protein binding

Biological Process: regulation of cell cycle

Research Articles on MS4A3

1. The C-terminal domain is important for the function of HTm4 in cell cycle regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MS4A3 sirna

Reference Product	PubMed Publications
MS4A1 sirna	>7 publications with MS4A3 and MS4A1
CDK2 sirna	>4 publications with MS4A3 and CDK2
CDKN3 sirna	>2 publications with MS4A3 and CDKN3
MS4A8B sirna	>1 publications with MS4A3 and MS4A8B

Diseases associated with MS4A3 sirna

Disease Name	Pubmed Publications
Leukemia Antibodies	>3 publications with MS4A3 and Leukemia
Leukemia, Myeloid, Acute Antibodies	>2 publications with MS4A3 and Leukemia, Myeloid, Acute
Lung Neoplasms Antibodies	>2 publications with MS4A3 and Lung Neoplasms
Lymphoma Antibodies	>2 publications with MS4A3 and Lymphoma
Ovarian Neoplasms Antibodies	>1 publications with MS4A3 and Ovarian Neoplasms
Multiple Myeloma Antibodies	>1 publications with MS4A3 and Multiple Myeloma
Chromosome Aberrations Antibodies	>1 publications with MS4A3 and Chromosome Aberrations
Breast Neoplasms Antibodies	>1 publications with MS4A3 and Breast Neoplasms
Carcinoma Antibodies	>1 publications with MS4A3 and Carcinoma
Carcinoma, Squamous Cell Antibodies	>1 publications with MS4A3 and Carcinoma, Squamous Cell

Organs/Tissues associated with MS4A3 sirna

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with MS4A3 and Blood
Lung Antibodies	>5 publications with MS4A3 and Lung
Bone Marrow Antibodies	>4 publications with MS4A3 and Bone Marrow
Brain Antibodies	>3 publications with MS4A3 and Brain
Liver Antibodies	>2 publications with MS4A3 and Liver
Prostate Antibodies	>1 publications with MS4A3 and Prostate