SCN2B siRNA – Sodium Channel Subunit Beta-2 (Human)

Name: SCN2B siRNA; Sodium Channel Subunit Beta-2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS8211375
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8211375

MBS8211375 is an siRNA targeting SCN2B. Also known as SCN2B siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit SCN2B expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SCN2B, siRNA

Full Product Name

SCN2B siRNA (Human)

Product Gene Name

SCN2B sirna

Product Synonym Names

Sodium channel subunit beta-2

Host

Synthetic

Species Reactivity

Human

Form/Format

Lyophilized powder

Purity/Purification

> 97%

Specificity

SCN2B siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Molecular Weight

24,326 Da

OMIM

601327

3D Structure

ModBase 3D Structure for O60939

Negative Control

siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.

Quality Control

Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.

Directions for Use

We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).

Components

We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SCN2B gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

Applications Tested/Suitable for SCN2B sirna

RNA Interference (RNAi)

Other Notes

Small volumes of SCN2B sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCN2B. It may not necessarily be applicable to this product.

NCBI GI #

4759066

NCBI GeneID

6327

NCBI Accession #

NP_004579.1

UniProt Primary Accession #

O60939

UniProt Secondary Accession #

O75302; Q9UNN3

UniProt Related Accession #

O60939

GenBank Nucleotide #

NM_004588.4

NCBI Official Full Name

sodium channel subunit beta-2

NCBI Official Synonym Full Names

sodium channel, voltage gated, type II beta subunit

NCBI Official Symbol

SCN2B

NCBI Official Synonym Symbols

ATFB14

UniProt Protein Name

Sodium channel subunit beta-2

Protein Family

Sodium channel

UniProt Gene Name

SCN2B

UniProt Entry Name

SCN2B_HUMAN

NCBI Protein Information

sodium channel subunit beta-2

NCBI Summary for SCN2B

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]

UniProt Comments for SCN2B

SCN2B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: voltage-gated sodium channel complex

Molecular Function: sodium channel regulator activity

Biological Process: synaptic transmission; nervous system development; response to pyrethroid; cardiac muscle contraction

Disease: Atrial Fibrillation, Familial, 14

Research Articles on SCN2B

1. With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCN2B sirna

Reference Product	PubMed Publications
SCN1B sirna	>22 publications with SCN2B and SCN1B
SCN5A sirna	>14 publications with SCN2B and SCN5A
SCN4B sirna	>11 publications with SCN2B and SCN4B
SCN2A sirna	>10 publications with SCN2B and SCN2A
SCN3B sirna	>10 publications with SCN2B and SCN3B
SCN8A sirna	>4 publications with SCN2B and SCN8A
SCN10A sirna	>1 publications with SCN2B and SCN10A

Pathways associated with SCN2B sirna

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Interaction Between L1 And Ankyrins Pathway antibodies	Interaction Between L1 And Ankyrins Pathway Diagram
L1CAM Interactions Pathway antibodies	L1CAM Interactions Pathway Diagram

Diseases associated with SCN2B sirna

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>12 publications with SCN2B and Heart Diseases
Arrhythmias, Cardiac Antibodies	>9 publications with SCN2B and Arrhythmias, Cardiac
Seizures Antibodies	>8 publications with SCN2B and Seizures
Disease Models, Animal Antibodies	>3 publications with SCN2B and Disease Models, Animal
Nerve Degeneration Antibodies	>2 publications with SCN2B and Nerve Degeneration
Ventricular Dysfunction, Left Antibodies	>1 publications with SCN2B and Ventricular Dysfunction, Left
Hypertension Antibodies	>1 publications with SCN2B and Hypertension
Neurobehavioral Manifestations Antibodies	>1 publications with SCN2B and Neurobehavioral Manifestations
Weight Loss Antibodies	>1 publications with SCN2B and Weight Loss
Fever Antibodies	>1 publications with SCN2B and Fever

Organs/Tissues associated with SCN2B sirna

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>25 publications with SCN2B and Brain
Heart Antibodies	>12 publications with SCN2B and Heart
Lung Antibodies	>1 publications with SCN2B and Lung