SLCO1B1 siRNA – Solute Carrier Organic Anion Transporter Family Member 1b1 (Human)

Name: SLCO1B1 siRNA; Human; MyBioSource
Brand: MyBioSource
SKU: MBS8204489
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8204489

MBS8204489 is an siRNA targeting SLCO1B1. Also known as SLCO1B1 siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit SLCO1B1 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SLCO1B1, siRNA

Full Product Name

SLCO1B1 siRNA (Human)

Product Gene Name

SLCO1B1 sirna

Product Synonym Names

LST1; OATP1B1; OATP2; OATPC; SLC21A6; Solute carrier organic anion transporter family member 1B1; Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6

Host

Synthetic

Species Reactivity

Human

Form/Format

Lyophilized powder

Purity/Purification

> 97%

Specificity

SLCO1B1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Molecular Weight

76,449 Da

OMIM

237450

3D Structure

ModBase 3D Structure for Q9Y6L6

Negative Control

siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.

Quality Control

Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.

Directions for Use

We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).

Components

We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human SLCO1B1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

Applications Tested/Suitable for SLCO1B1 sirna

RNA Interference (RNAi)

Other Notes

Small volumes of SLCO1B1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLCO1B1. It may not necessarily be applicable to this product.

NCBI GI #

225543525

NCBI GeneID

10599

NCBI Accession #

NP_006437.3

UniProt Primary Accession #

Q9Y6L6

UniProt Secondary Accession #

Q29R64; Q9NQ37; Q9UBF3; Q9UH89; B2R7G2

UniProt Related Accession #

Q9Y6L6

GenBank Nucleotide #

NM_006446.4

NCBI Official Full Name

solute carrier organic anion transporter family member 1B1

NCBI Official Synonym Full Names

solute carrier organic anion transporter family, member 1B1

NCBI Official Symbol

SLCO1B1

NCBI Official Synonym Symbols

LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6

UniProt Protein Name

Solute carrier organic anion transporter family member 1B1

UniProt Synonym Protein Names

Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6

Protein Family

Solute carrier organic anion transporter family

UniProt Gene Name

SLCO1B1

UniProt Synonym Gene Names

LST1; OATP1B1; OATP2; OATPC; SLC21A6; LST-1; OATP-2

UniProt Entry Name

SO1B1_HUMAN

NCBI Protein Information

solute carrier organic anion transporter family member 1B1

NCBI Summary for SLCO1B1

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

UniProt Comments for SLCO1B1

SLCO1B1: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B1 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.

Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12p

Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: sodium-independent organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport

Disease: Hyperbilirubinemia, Rotor Type

Research Articles on SLCO1B1

1. Results show that patients carrying at least one SLCO1b1 haplotype have increased risk of ATDH

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SLCO1B1 sirna

Reference Product	PubMed Publications
ABCC2 sirna	>51 publications with SLCO1B1 and ABCC2
ABCB11 sirna	>9 publications with SLCO1B1 and ABCB11
SLC10A1 sirna	>9 publications with SLCO1B1 and SLC10A1
ABCC3 sirna	>8 publications with SLCO1B1 and ABCC3
NR1I2 sirna	>6 publications with SLCO1B1 and NR1I2
SLC22A8 sirna	>5 publications with SLCO1B1 and SLC22A8

Pathways associated with SLCO1B1 sirna

Products by Pathway	Pathway Diagram
Bile Acid And Bile Salt Metabolism Pathway antibodies	Bile Acid And Bile Salt Metabolism Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Codeine And Morphine Metabolism Pathway antibodies	Codeine And Morphine Metabolism Pathway Diagram
Drug Induction Of Bile Acid Pathway antibodies	Drug Induction Of Bile Acid Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Recycling Of Bile Acids And Salts Pathway antibodies	Recycling Of Bile Acids And Salts Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with SLCO1B1 sirna

Disease Name	Pubmed Publications
Muscular Diseases Antibodies	>51 publications with SLCO1B1 and Muscular Diseases
Cardiovascular Diseases Antibodies	>46 publications with SLCO1B1 and Cardiovascular Diseases
Liver Diseases Antibodies	>38 publications with SLCO1B1 and Liver Diseases
Dyslipidemias Antibodies	>29 publications with SLCO1B1 and Dyslipidemias
Hyperlipidemias Antibodies	>27 publications with SLCO1B1 and Hyperlipidemias
Hypercholesterolemia Antibodies	>25 publications with SLCO1B1 and Hypercholesterolemia
Rhabdomyolysis Antibodies	>24 publications with SLCO1B1 and Rhabdomyolysis
Heart Diseases Antibodies	>24 publications with SLCO1B1 and Heart Diseases
Drug-Related Side Effects and Adverse Reactions Antibodies	>19 publications with SLCO1B1 and Drug-Related Side Effects and Adverse Reactions
Drug-Induced Liver Injury Antibodies	>18 publications with SLCO1B1 and Drug-Induced Liver Injury

Organs/Tissues associated with SLCO1B1 sirna

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>189 publications with SLCO1B1 and Liver
Spleen Antibodies	>1 publications with SLCO1B1 and Spleen