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TRPM3 siRNA – Transient Receptor Potential Cation Channel Subfamily M Member 3 Isoform K (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8207908

MBS8207908 is an siRNA targeting TRPM3. Also known as TRPM3 siRNA (Human). Reactive in Human. Host: Synthetic. siRNA to inhibit TRPM3 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRPM3, siRNA
Full Product Name
TRPM3 siRNA (Human)
Product Gene Name
TRPM3 sirna
Product Synonym Names
KIAA1616; LTRPC3; Transient receptor potential cation channel subfamily M member 3; Long transient receptor potential channel 3; LTrpC-3; LTrpC3; Melastatin-2; MLSN2
Host
Synthetic
Species Reactivity
Human
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
TRPM3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
25,159 Da
OMIM
608961
3D Structure
ModBase 3D Structure for Q9HCF6
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human TRPM3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for TRPM3 sirna
RNA Interference (RNAi)

Other Notes

Small volumes of TRPM3 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPM3. It may not necessarily be applicable to this product.

NCBI GI #
154091314
NCBI GeneID
80036
NCBI Accession #
NP_001007472.2
UniProt Primary Accession #
Q9HCF6
UniProt Secondary Accession #
Q5VW02; Q5VW03; Q5VW04; Q5W5T7; Q86SH0; Q86SH6; Q86UL0; Q86WK1; Q86WK2; A2A3F6; A9Z1Y7
UniProt Related Accession #
Q9HCF6
GenBank Nucleotide #
NM_001007471.2
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 3 isoform k
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 3
NCBI Official Symbol
TRPM3
NCBI Official Synonym Symbols
GON-2; MLSN2; LTRPC3
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 3
UniProt Synonym Protein Names
Long transient receptor potential channel 3; LTrpC-3; LTrpC3; Melastatin-2; MLSN2
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPM3
UniProt Synonym Gene Names
KIAA1616; LTRPC3; LTrpC-3; LTrpC3; MLSN2
UniProt Entry Name
TRPM3_HUMAN
NCBI Protein Information
transient receptor potential cation channel subfamily M member 3

NCBI Summary for TRPM3

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for TRPM3

TRPM3: a transient receptor potential (TRP) ion channel. Mediates constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by calcium store depletion and muscarinic receptor activation. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Ten alternatively spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium channel activity; cation channel activity; calcium activated cation channel activity

Biological Process: detection of temperature stimulus; sensory perception of temperature stimulus; transmembrane transport; cation transport
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Research Articles on TRPM3

1. TRPM3 channel activation changes the gene expression pattern of the cells by activating transcription of c-Jun-, ATF2-, and TCF-controlled genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TRPM3 sirna

 Reference Product  PubMed Publications
 TRPV4 sirna  >30 publications with TRPM3 and TRPV4
 TRPV1 sirna  >25 publications with TRPM3 and TRPV1
 TRPV2 sirna  >17 publications with TRPM3 and TRPV2
 TRPA1 sirna  >15 publications with TRPM3 and TRPA1
 TRPV3 sirna  >14 publications with TRPM3 and TRPV3
 TRPC1 sirna  >13 publications with TRPM3 and TRPC1
 TRPV5 sirna  >10 publications with TRPM3 and TRPV5
 TRPV6 sirna  >7 publications with TRPM3 and TRPV6
 PKD2 sirna  >1 publications with TRPM3 and PKD2

Pathways associated with TRPM3 sirna

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with TRPM3 sirna

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >10 publications with TRPM3 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >10 publications with TRPM3 and Nervous System Diseases
 Inflammation Antibodies  >8 publications with TRPM3 and Inflammation
 Brain Diseases Antibodies  >5 publications with TRPM3 and Brain Diseases
 Hypertension Antibodies  >3 publications with TRPM3 and Hypertension
 Eye Abnormalities Antibodies  >1 publications with TRPM3 and Eye Abnormalities
 Atherosclerosis Antibodies  >1 publications with TRPM3 and Atherosclerosis
 Poisoning Antibodies  >1 publications with TRPM3 and Poisoning
 Abnormalities, Multiple Antibodies  >1 publications with TRPM3 and Abnormalities, Multiple

Organs/Tissues associated with TRPM3 sirna

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with TRPM3 and Brain
 Kidney Antibodies  >12 publications with TRPM3 and Kidney
 Eye Antibodies  >8 publications with TRPM3 and Eye
 Blood Antibodies  >7 publications with TRPM3 and Blood
 Mouth Antibodies  >6 publications with TRPM3 and Mouth
 Embryonic Tissue Antibodies  >4 publications with TRPM3 and Embryonic Tissue
 Skin Antibodies  >3 publications with TRPM3 and Skin
 Testis Antibodies  >3 publications with TRPM3 and Testis
 Spinal Cord Antibodies  >2 publications with TRPM3 and Spinal Cord
 Prostate Antibodies  >2 publications with TRPM3 and Prostate
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