7Beta-Hydroxycholesterol Inhibitor

Name: 7Beta-Hydroxycholesterol Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5760085
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5760085

7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

7Beta-Hydroxycholesterol, Inhibitor

Full Product Name

7Beta-Hydroxycholesterol

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

402.65

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C27H46O2

SMILES

CC(C)CCC[C@@H](C)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@H](C3)O)C3=C3)[C@@H]1[C@@H]2[C@H]3O

CAS Number

566-27-8

Target & IC50

LDL
Calcium Channel
MAPK

In Vitro

7beta-OHC decreased clonogenic survival of NCI-H460 in a dose dependent pattern. 7beta-OHC induced apoptosis in NCI-H460, with the characteristic features like increase in sub-G(1) hypodiploid (apoptotic) cells, and apoptotic body formation, as evidenced by flow cytometry and fluorescence microscope, respectively. Apoptosis was also associated with loss of mitochondrial transmembrane potential, and the activation of caspases 9 and 3. 7beta-OHC resulted in generation of reactive oxygen species (ROS) during apoptosis[1]

Product Categories/Family for 7Beta-Hydroxycholesterol, inhibitor

Metabolism; LDL; Membrane transporter/Ion channel; MAPK

Product References and Citations for 7Beta-Hydroxycholesterol, inhibitor

Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells. Biol. Pharm. Bull., 2005, 28(8):1377-80.
Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells. Biol. Pharm. Bull., 2005, 28(8):1377-80.
Effects of combinations of 7beta-hydroxycholesterol and anticancer drugs or ionizing radiation on the proliferation of cultured tumor cells. Anticancer Res., 2002, 22(2A):943-8.

Other Notes

Small volumes of 7Beta-Hydroxycholesterol, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 7Beta-Hydroxycholesterol purchase

MBS5760085 is an inhibitor targeting 7Beta-Hydroxycholesterol.