8-Chloroadenosine Inhibitor

8-Chloroadenosine is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

1 Dicitor A Grass ES Caragli M Borgh MO Gaudenz G Hoflan LJ Persan L Vital G Th cAM analog hav poten anti-proliferativ effect o medullar thyroi cance cel lines Endocrine 201 Jan 1(1):101-12 doi 10.1007/s12020-015-0597-7 PubMe PMID 25863490.
2 Zhan e a (2004 Exposur o PUMA lun cance cell t 8-chloro-adenosin induce G2/ arres an mitoti catastrophe Neoplasi 80 PMID 1572080 href="javascript:void(0) rel="nofollow >
3 Stellrech CM Vangapand HV L XF Ma W Shent S AT directe agent 8-chloro-adenosine induce AM activate protei kinas activity leadin t autophagi cel deat i breas cance cells Hemato Oncol 201 Ma 14 :23 doi 10.1186/1756-8722-7-23 PubMe PMID 24628795 PubMe Centra PMCID PMC4007639 href="javascript:void(0) rel="nofollow >
4 Ha YY Zho Z Ca JX Ji YQ L SY N JH A GS Zhan YX Ji HT E2F1-mediate DN damag i implicate i 8-Cl-adenosine-induce chromosom missegregatio an apoptosi i PUMA lun cance H129 cells Mo Cel Biochem 201 Dec 84(1-2):187-96 doi 10.1007/s11010-013-1797-1 PubMe PMID 24037421.

Small volumes of 8-Chloroadenosine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5772090 is an inhibitor targeting 8-Chloroadenosine.