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DAPT (GSI-IX) Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS384798

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. More details

$150 / 5 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DAPT (GSI-IX), Inhibitor
Full Product Name
DAPT (GSI-IX)
Product Synonym Names
GSIIX
Form/Format
Powder
Purity/Purification
>98%
Concentration
0.1 mM: 23.12 mL (1 mg); 115.61 mL (5 mg); 231.21mL (10 mg)
0.5 mM: 4.62 mL (1 mg); 23.12 mL (5 mg); 46.24 mL (10 mg)
1 mM: 2.31 mL (1 mg); 11.56 mL (5 mg); 23.12 mL (10 mg)
5 mM: 0.46 mL (1 mg); 2.31 mL (5 mg); 4.62 mL (10 mg) (lot specific)
Preparation and Storage
at -20 degree C 3 years Powder
Molecular Weight
432.5
CAS Number
208255-80-5
Formula
C23H26F2N2O4
SMILES
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
Actions
Inhibitor
In Vivo Solvent
5% DMSO/95% Corn oil
Solubility (DMSO)
86 mg/mL (198.86 mM)
Solubility (Ethanol)
50 mg/mL (115.61 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.

Chemical Structure of DAPT (GSI-IX), inhibitor

DAPT (GSI-IX) Inhibitor – Cat# MBS384798

Product References and Citations for DAPT (GSI-IX), inhibitor

Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386

Other Notes

Small volumes of DAPT (GSI-IX), inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DAPT (GSI-IX) purchase

MBS384798 is an inhibitor targeting DAPT (GSI-IX).
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