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PD184161 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5773139

PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100nM) in a time- and concentration-dependent manner[1]. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PD184161, Inhibitor
Full Product Name
PD184161
Product Gene Name
PD184161, inhibitor
Purity/Purification
99.09%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
557.56
SMILES
Fc1c(F)c(Nc2ccc(I)cc2Cl)c(cc1Br)C(=O)NOCC1CC1
Formula
C17H13BrClF2IN2O2
CAS Number
212631-67-9
Target
MEK
MEK1/2: 10-100nM
Solubility
DMSO: 29mg/mL (52.00 mM)
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
In vivo, tumor xenograft P-ERK levels were significantly reduced 3 to 12hours after an oral dose of PD184161 (P <.05). Contrarily, tumor xenograft P-ERK levels following long-term (24 days) daily dosing of PD184161 were refractory to this signaling effect. PD184161 significantly suppressed tumor engraftment and initial growth (P <.0001); however, established tumors were not significantly affected. In conclusion, PD184161 has Antitumor effects in HCC in vivo that appear to correlate with suppression of MEK activity [1].

Product Categories/Family for PD184161, inhibitor

MAPK

Structure of PD184161, inhibitor

PD184161, CAS 212631-67-9
PD184161 Inhibitor – Cat# MBS5773139

Structure of PD184161, inhibitor

PD184161, CAS 212631-67-9
PD184161 Inhibitor, Structure – Cat# MBS5773139

Product References and Citations for PD184161, inhibitor

1 Klein P J.,Schmidt C.M.,Wiesenauer C.A. e al Th effect o nove ME inhibito PD18416 o MEK-ER signalin an growt i PUMA live cancer Neoplasi 8(1) 1- (2006).

Other Notes

Small volumes of PD184161, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PD184161 purchase

MBS5773139 is an inhibitor targeting PD184161.
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