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SLC6A1 Lysate – Tissue Lysate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8419750

Human SLC6A1 Protein Lysate 20ug is provided as a Lyophilized powder.This is a Recombinant Protein Lysate produced in HEK293T cells. This protein lysate can be reconsituted using SDS Sample Buffer. More details

$390 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SLC6A1, Lysate
Full Product Name
Human SLC6A1 Protein Lysate
Product Gene Name
SLC6A1 lysate
Product Synonym Names
SLC6A1; GABATHG; GABATR; GAT1; MAE
Host
Human
Form/Format
Lyophilized
Preparation and Storage
Store at -20 degree C
Once reconsituted, aliquot and store any remaining material at-20 degree C to avoid repeated freeze-thaw cycles.
Molecular Weight
67kDa
OMIM
137165
3D Structure
ModBase 3D Structure for P30531

Other Notes

Small volumes of SLC6A1 lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC6A1 purchase

MBS8419750 is a lysate targeting SLC6A1. Also known as Human SLC6A1 Protein Lysate. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC6A1. It may not necessarily be applicable to this product.

NCBI GI #
188528618
NCBI GeneID
6529
NCBI Accession #
NP_003033
UniProt Primary Accession #
P30531
UniProt Related Accession #
P30531
GenBank Nucleotide #
NM_003042
NCBI Official Full Name
sodium- and chloride-dependent GABA transporter 1 isoform a
NCBI Official Synonym Full Names
solute carrier family 6 member 1
NCBI Official Symbol
SLC6A1
NCBI Official Synonym Symbols
MAE; GAT1; GABATR; GABATHG
UniProt Protein Name
Sodium- and chloride-dependent GABA transporter 1
UniProt Synonym Protein Names
Solute carrier family 6 member 1
Protein Family
Sodium- and chloride-dependent GABA transporter
UniProt Gene Name
SLC6A1
UniProt Synonym Gene Names
GABATR; GABT1; GAT1; GAT-1
UniProt Entry Name
SC6A1_HUMAN
NCBI Protein Information
sodium- and chloride-dependent GABA transporter 1

NCBI Summary for SLC6A1

The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]

UniProt Comments for SLC6A1

SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cell surface; membrane; integral to plasma membrane; axon; plasma membrane; integral to membrane

Molecular Function: gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity

Biological Process: response to purine; response to toxin; neurotransmitter secretion; learning; response to cocaine; response to estradiol stimulus; response to sucrose stimulus; synaptic transmission; transport; response to lead ion; gamma-aminobutyric acid import; negative regulation of synaptic transmission, GABAergic; response to calcium ion; transmembrane transport; protein homooligomerization; positive regulation of gamma-aminobutyric acid secretion

Disease: Myoclonic-atonic Epilepsy
Show more

Research Articles on SLC6A1

1. This study demonstrated that SLC6A1 is an important contributor to childhood epilepsy and that reduced GAT-1 function is a common consequence of epilepsy-causing SLC6A1 variants.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SLC6A1 lysate

 Reference Product  PubMed Publications
 STX1A lysate  >7 publications with SLC6A1 and STX1A

Pathways associated with SLC6A1 lysate

 Products by Pathway  Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Reuptake Of GABA Pathway antibodies  Reuptake Of GABA Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with SLC6A1 lysate

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >49 publications with SLC6A1 and Nervous System Diseases
 Epilepsy Antibodies  >42 publications with SLC6A1 and Epilepsy
 Brain Diseases Antibodies  >38 publications with SLC6A1 and Brain Diseases
 Seizures Antibodies  >25 publications with SLC6A1 and Seizures
 Schizophrenia Antibodies  >18 publications with SLC6A1 and Schizophrenia
 Drug Toxicity Antibodies  >10 publications with SLC6A1 and Drug Toxicity
 Pain Antibodies  >9 publications with SLC6A1 and Pain
 Memory Disorders Antibodies  >4 publications with SLC6A1 and Memory Disorders
 Learning Disorders Antibodies  >4 publications with SLC6A1 and Learning Disorders
 Mood Disorders Antibodies  >4 publications with SLC6A1 and Mood Disorders

Organs/Tissues associated with SLC6A1 lysate

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >198 publications with SLC6A1 and Brain
 Embryonic Tissue Antibodies  >6 publications with SLC6A1 and Embryonic Tissue
 Testis Antibodies  >5 publications with SLC6A1 and Testis
 Liver Antibodies  >5 publications with SLC6A1 and Liver
 Stomach Antibodies  >2 publications with SLC6A1 and Stomach
 Intestine Antibodies  >2 publications with SLC6A1 and Intestine
 Bone Antibodies  >1 publications with SLC6A1 and Bone
 Uncharacterized Tissue Antibodies  >1 publications with SLC6A1 and Uncharacterized Tissue
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