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Glutaredoxin-1 (GLRX) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS609243

Glutaredoxin (Grx), also known as thiol transferase, is a small heatstable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First… More details

$620 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glutaredoxin-1 (GLRX), Monoclonal Antibody
Full Product Name
Glutaredoxin-1 (Glutaredoxin 1, Thioltransferase-1, TTase-1, GLRX, GRX)
Product Gene Name
Product Synonym Names
Anti -Glutaredoxin-1 (Glutaredoxin 1, Thioltransferase-1, TTase-1, GLRX, GRX)
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
10K210
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in Hepes, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
Purity/Purification
Ascites
Ascites
Specificity
Recognizes human Glutaredoxin I.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
11,776 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (95149553..95158577, complement). Location: 5q14
OMIM
600443
3D Structure
ModBase 3D Structure for P35754
Immunogen
Recombinant human protein purified from E.coli.

Product Categories/Family for anti-GLRX antibody

Applications Tested/Suitable for anti-GLRX antibody
ELISA (EL/EIA), Immunoprecipitation (IP)
Application Notes for anti-GLRX antibody
Suitable for use in ELISA and Immunoprecipitation.
Dilution: Immunoprecipitation: 1-2ul/400ul lysates

Other Notes

Small volumes of anti-GLRX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLRX purchase

MBS609243 is an antibody targeting GLRX. Also known as Glutaredoxin-1 (Glutaredoxin 1, Thioltransferase-1, TTase-1, GLRX, GRX). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRX. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glutaredoxin-1
NCBI Official Synonym Full Names
glutaredoxin (thioltransferase)
NCBI Official Symbol
GLRX
NCBI Official Synonym Symbols
GRX; GRX1; MGC117407
UniProt Protein Name
Glutaredoxin-1
UniProt Synonym Protein Names
Thioltransferase-1
Protein Family
UniProt Gene Name
GLRX
UniProt Synonym Gene Names
GRX
UniProt Entry Name
GLRX1_HUMAN
NCBI Protein Information
glutaredoxin-1; TTase-1; OTTHUMP00000149979; OTTHUMP00000222608; OTTHUMP00000222609; thioltransferase-1

NCBI Summary for GLRX

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
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UniProt Comments for GLRX

GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 5q14

Cellular Component: mitochondrion; cytosol; nucleus

Molecular Function: electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; nucleobase, nucleoside and nucleotide interconversion; positive regulation of membrane potential
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLRX antibody

 Reference Product  PubMed Publications
 MAP3K5 antibody  >2 publications with GLRX and MAP3K5

Organs/Tissues associated with anti-GLRX antibody

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