STC2 Antibody – Mouse Monoclonal

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

STC2: a secreted protein that has an anti-hypocalcemic action on calcium and phosphate homeostasis. Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leucocytes.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: Golgi apparatus; extracellular space; perinuclear region of cytoplasm; endoplasmic reticulum

Molecular Function: enzyme binding; protein homodimerization activity; hormone activity; heme binding

Biological Process: cellular calcium ion homeostasis; response to peptide hormone stimulus; response to vitamin D; negative regulation of multicellular organism growth; unfolded protein response; decidualization; response to oxidative stress; regulation of hormone biosynthetic process; embryo implantation