RAB21 Antibody – Mouse Monoclonal

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

RAB21: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric, Rab; G protein, monomeric; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: cleavage furrow; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; endosome; focal adhesion; internal side of plasma membrane; trans-Golgi network; vesicle membrane

Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding

Biological Process: anterograde axon cargo transport; intracellular protein transport; metabolic process; nucleocytoplasmic transport; positive regulation of dendrite morphogenesis; positive regulation of receptor-mediated endocytosis; regulation of axon extension; regulation of exocytosis; small GTPase mediated signal transduction