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CD122 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2558224

CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine… More details

$175 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD122, Monoclonal Antibody
Full Product Name
Anti-Mouse CD122 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) [5H4]
Product Gene Name
anti-CD122 antibody
Product Synonym Gene Name
Mouse CD122
Product Synonym Names
Interleukin-2 receptor subunit beta; Il2rb; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; CD122
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
5H4
Host
Rat
Species Reactivity
Mouse
Form/Format
PBS with 0.05% Proclin300, 1% BSA
Concentration
0.5 mg/mL (lot specific)
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
Matching Pairs
Antibody: CD122 (MBS2558224)
Isotype Control: IgG2a Clone #2A3 (MBS2557860)
3D Structure
ModBase 3D Structure for P16297
Conjugation
PE/Cyanine5.5
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD122 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD122 antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Other Notes

Small volumes of anti-CD122 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD122 purchase

MBS2558224 is an antibody targeting CD122. Also known as Anti-Mouse CD122 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) [5H4]. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD122. It may not necessarily be applicable to this product.

NCBI GI #
6680427
NCBI GeneID
16185
NCBI Accession #
NP_032394.1
UniProt Primary Accession #
P16297
UniProt Related Accession #
P16297
GenBank Nucleotide #
NP_032394.1
NCBI Official Full Name
interleukin-2 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 2 receptor, beta chain
NCBI Official Symbol
Il2rb
NCBI Official Synonym Symbols
p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta
UniProt Protein Name
Interleukin-2 receptor subunit beta
UniProt Synonym Protein Names
High affinity IL-2 receptor subunit beta; p70-75; CD_antigen: CD122
Protein Family
Interleukin-2 receptor
UniProt Gene Name
Il2rb
UniProt Synonym Gene Names
IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB
UniProt Entry Name
IL2RB_MOUSE
NCBI Protein Information
interleukin-2 receptor subunit beta

NCBI Summary for CD122

The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]

UniProt Comments for CD122

IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; external side of plasma membrane; integral to membrane; membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-2 binding; interleukin-2 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; natural killer cell activation; negative regulation of apoptosis
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Research Articles on CD122

1. Diabetes was accelerated in male and female NOD mice in which IL-2Rbeta signaling was modestly and selectively reduced in T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD122 antibody

 Reference Product  PubMed Publications
 Il15 antibody  >30 publications with CD122 and Il15
 Il2ra antibody  >23 publications with CD122 and Il2ra
 Il2rg antibody  >10 publications with CD122 and Il2rg
 Jak3 antibody  >6 publications with CD122 and Jak3
 Jak1 antibody  >6 publications with CD122 and Jak1
 Jak2 antibody  >3 publications with CD122 and Jak2
 Shc1 antibody  >2 publications with CD122 and Shc1
 Syk antibody  >1 publications with CD122 and Syk

Pathways associated with anti-CD122 antibody

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram

Diseases associated with anti-CD122 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >25 publications with CD122 and Inflammation
 Arthritis, Rheumatoid Antibodies  >12 publications with CD122 and Arthritis, Rheumatoid
 Necrosis Antibodies  >10 publications with CD122 and Necrosis
 Hypersensitivity Antibodies  >10 publications with CD122 and Hypersensitivity
 Asthma Antibodies  >9 publications with CD122 and Asthma
 Lung Diseases Antibodies  >9 publications with CD122 and Lung Diseases
 Liver Diseases Antibodies  >7 publications with CD122 and Liver Diseases
 Adenocarcinoma Antibodies  >4 publications with CD122 and Adenocarcinoma
 Chromosome Aberrations Antibodies  >4 publications with CD122 and Chromosome Aberrations
 Neoplasms, Experimental Antibodies  >4 publications with CD122 and Neoplasms, Experimental

Organs/Tissues associated with anti-CD122 antibody

 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >13 publications with CD122 and Spleen
 Bone Antibodies  >11 publications with CD122 and Bone
 Liver Antibodies  >8 publications with CD122 and Liver
 Lung Antibodies  >7 publications with CD122 and Lung
 Thymus Antibodies  >7 publications with CD122 and Thymus
 Intestine Antibodies  >4 publications with CD122 and Intestine
 Heart Antibodies  >3 publications with CD122 and Heart
 Pancreas Antibodies  >1 publications with CD122 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with CD122 and Embryonic Tissue
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