SPARC ELISA Kit for Mouse

SPARC: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: basement membrane; cell surface; cytoplasm; extracellular region; extracellular space; intracellular; nuclear matrix; nucleus; platelet alpha granule membrane; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; collagen binding; extracellular matrix binding; metal ion binding; protein binding

Biological Process: lung development; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; regulation of cell morphogenesis; regulation of cell proliferation; signal transduction