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ACVR1C siRNA – Activin Receptor Type-1c Isoform 1 (Mouse)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8211650

MBS8211650 is an siRNA targeting ACVR1C. Also known as ACVR1C siRNA (Mouse). Reactive in Mouse. Host: Synthetic. siRNA to inhibit ACVR1C expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACVR1C, siRNA
Full Product Name
ACVR1C siRNA (Mouse)
Product Gene Name
ACVR1C sirna
Product Synonym Names
ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
Host
Synthetic
Species Reactivity
Mouse
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
ACVR1C siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
54,700 Da
3D Structure
ModBase 3D Structure for Q8K348
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse ACVR1C gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for ACVR1C sirna
RNA Interference (RNAi)

Other Notes

Small volumes of ACVR1C sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACVR1C. It may not necessarily be applicable to this product.

NCBI GI #
161333831
NCBI GeneID
269275
NCBI Accession #
NP_001104500.1
UniProt Primary Accession #
Q8K348
UniProt Secondary Accession #
A2AJR4
UniProt Related Accession #
Q8K348
GenBank Nucleotide #
NM_001111030.1
NCBI Official Full Name
activin receptor type-1C isoform 1
NCBI Official Synonym Full Names
activin A receptor, type IC
NCBI Official Symbol
Acvr1c
NCBI Official Synonym Symbols
ALK7; Alk-7; ACVRLK7; C230097P10
UniProt Protein Name
Activin receptor type-1C
UniProt Synonym Protein Names
Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
Protein Family
Activin receptor
UniProt Gene Name
Acvr1c
UniProt Synonym Gene Names
ACTR-IC; ALK-7
UniProt Entry Name
ACV1C_MOUSE
NCBI Protein Information
activin receptor type-1C

UniProt Comments for ACVR1C

ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Cellular Component: cell surface; membrane; cytoplasm; integral to membrane; plasma membrane; activin receptor complex

Molecular Function: metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; activin receptor activity, type I; growth factor binding; transferase activity, transferring phosphorus-containing groups; activin binding; kinase activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: transforming growth factor beta receptor complex assembly; response to dietary excess; trophectodermal cell proliferation; in utero embryonic development; apoptosis; positive regulation of apoptosis; activin receptor signaling pathway; positive regulation of caspase activity; protein amino acid phosphorylation; negative regulation of insulin secretion; response to insulin stimulus; regulation of apoptosis; sequestering of lipid; apoptotic nuclear changes; transmembrane receptor protein serine/threonine kinase signaling pathway; response to glucose stimulus; cell differentiation; determination of left/right symmetry; phosphorylation
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Research Articles on ACVR1C

1. ALK7 signaling contributes to diet-induced catecholamine resistance in adipose tissue; ALK7 inhibitors may have therapeutic value in human obesity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACVR1C sirna

 Reference Product  PubMed Publications
 Nodal sirna  >28 publications with ACVR1C and Nodal
 Smad2 sirna  >24 publications with ACVR1C and Smad2
 Smad3 sirna  >18 publications with ACVR1C and Smad3
 Smad4 sirna  >4 publications with ACVR1C and Smad4
 Tdgf1 sirna  >4 publications with ACVR1C and Tdgf1
 Acvr2a sirna  >2 publications with ACVR1C and Acvr2a
 Smad5 sirna  >1 publications with ACVR1C and Smad5
 Bmp4 sirna  >1 publications with ACVR1C and Bmp4

Pathways associated with ACVR1C sirna

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with ACVR1C sirna

 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >5 publications with ACVR1C and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >3 publications with ACVR1C and Breast Neoplasms
 Fibrosis Antibodies  >3 publications with ACVR1C and Fibrosis
 Disease Models, Animal Antibodies  >3 publications with ACVR1C and Disease Models, Animal
 Diabetes Mellitus Antibodies  >3 publications with ACVR1C and Diabetes Mellitus
 Nervous System Diseases Antibodies  >2 publications with ACVR1C and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with ACVR1C and Liver Diseases
 Lung Neoplasms Antibodies  >2 publications with ACVR1C and Lung Neoplasms
 Kidney Diseases Antibodies  >2 publications with ACVR1C and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with ACVR1C and Liver Neoplasms

Organs/Tissues associated with ACVR1C sirna

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >10 publications with ACVR1C and Other
 Brain Antibodies  >9 publications with ACVR1C and Brain
 Embryonic Tissue Antibodies  >5 publications with ACVR1C and Embryonic Tissue
 Lung Antibodies  >3 publications with ACVR1C and Lung
 Mammary Gland Antibodies  >1 publications with ACVR1C and Mammary Gland
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