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AGTR2 siRNA – Type-2 Angiotensin II Receptor (Mouse)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8208151

MBS8208151 is an siRNA targeting AGTR2. Also known as AGTR2 siRNA (Mouse). Reactive in Mouse. Host: Synthetic. siRNA to inhibit AGTR2 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AGTR2, siRNA
Full Product Name
AGTR2 siRNA (Mouse)
Product Gene Name
AGTR2 sirna
Product Synonym Names
Type-2 angiotensin II receptor; Angiotensin II type-2 receptor; AT2
Host
Synthetic
Species Reactivity
Mouse
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
AGTR2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
41,374 Da
3D Structure
ModBase 3D Structure for P35374
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse AGTR2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for AGTR2 sirna
RNA Interference (RNAi)

Other Notes

Small volumes of AGTR2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AGTR2. It may not necessarily be applicable to this product.

NCBI GI #
6680672
NCBI GeneID
11609
NCBI Accession #
NP_031455.1
UniProt Primary Accession #
P35374
UniProt Related Accession #
P35374
GenBank Nucleotide #
NM_007429.5
NCBI Official Full Name
type-2 angiotensin II receptor
NCBI Official Synonym Full Names
angiotensin II receptor, type 2
NCBI Official Symbol
Agtr2
NCBI Official Synonym Symbols
AI316812; AW107640
UniProt Protein Name
Type-2 angiotensin II receptor
UniProt Synonym Protein Names
Angiotensin II type-2 receptor; AT2
Protein Family
Type-2 angiotensin II receptor
UniProt Gene Name
Agtr2
UniProt Synonym Gene Names
AT2
UniProt Entry Name
AGTR2_MOUSE
NCBI Protein Information
type-2 angiotensin II receptor

UniProt Comments for AGTR2

AT2: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function: G-protein coupled receptor activity; signal transducer activity; angiotensin type II receptor activity; peptide hormone binding; transcription factor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of icosanoid secretion; regulation of transcription factor import into nucleus; negative regulation of heart rate; negative regulation of nerve growth factor receptor signaling pathway; regulation of vasodilation; positive regulation of transcription, DNA-dependent; renin-angiotensin regulation of aldosterone production; dopamine biosynthetic process; positive regulation of vasodilation; signal transduction; angiotensin mediated vasodilation involved in regulation of systemic arterial blood pressure; regulation of apoptosis; cerebellar cortex development; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; cell surface receptor linked signal transduction; positive regulation of cell proliferation; negative regulation of neuron apoptosis; inflammatory response; cellular sodium ion homeostasis; positive regulation of nitric-oxide synthase activity; brain renin-angiotensin system; G-protein coupled receptor protein signaling pathway; negative regulation of fibroblast proliferation; G-protein signaling, coupled to cGMP nucleotide second messenger; positive regulation of cytokine secretion
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Research Articles on AGTR2

1. AT2R signaling positively regulates myoblast differentiation and potentiates skeletal muscle regenerative potential.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AGTR2 sirna

 Reference Product  PubMed Publications
 Agt sirna  >58 publications with AGTR2 and Agt
 Kng1 sirna  >1 publications with AGTR2 and Kng1
 Cxcl12 sirna  >1 publications with AGTR2 and Cxcl12

Pathways associated with AGTR2 sirna

 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with AGTR2 sirna

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1053 publications with AGTR2 and Cardiovascular Diseases
 Hypertension Antibodies  >887 publications with AGTR2 and Hypertension
 Heart Diseases Antibodies  >476 publications with AGTR2 and Heart Diseases
 Hypertrophy Antibodies  >292 publications with AGTR2 and Hypertrophy
 Kidney Diseases Antibodies  >275 publications with AGTR2 and Kidney Diseases
 Disease Models, Animal Antibodies  >227 publications with AGTR2 and Disease Models, Animal
 Heart Failure Antibodies  >184 publications with AGTR2 and Heart Failure
 Fibrosis Antibodies  >168 publications with AGTR2 and Fibrosis
 Myocardial Infarction Antibodies  >160 publications with AGTR2 and Myocardial Infarction
 Cardiomegaly Antibodies  >158 publications with AGTR2 and Cardiomegaly

Organs/Tissues associated with AGTR2 sirna

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >758 publications with AGTR2 and Heart
 Kidney Antibodies  >672 publications with AGTR2 and Kidney
 Brain Antibodies  >345 publications with AGTR2 and Brain
 Lung Antibodies  >71 publications with AGTR2 and Lung
 Embryonic Tissue Antibodies  >66 publications with AGTR2 and Embryonic Tissue
 Ovary Antibodies  >43 publications with AGTR2 and Ovary
 Eye Antibodies  >31 publications with AGTR2 and Eye
 Pancreas Antibodies  >28 publications with AGTR2 and Pancreas
 Skin Antibodies  >27 publications with AGTR2 and Skin
 Spinal Cord Antibodies  >13 publications with AGTR2 and Spinal Cord
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