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CAT siRNA – Catalase (Mouse)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8223409

MBS8223409 is an siRNA targeting CAT. Also known as CAT siRNA (Mouse). Reactive in Mouse. Host: Synthetic. siRNA to inhibit CAT expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAT, siRNA
Full Product Name
CAT siRNA (Mouse)
Product Gene Name
CAT sirna
Product Synonym Names
CAS-1; CAS1; Catalase
Host
Synthetic
Species Reactivity
Mouse
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
CAT siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
59,795 Da
3D Structure
ModBase 3D Structure for P24270
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse CAT gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for CAT sirna
RNA Interference (RNAi)

Other Notes

Small volumes of CAT sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CAT. It may not necessarily be applicable to this product.

NCBI GI #
157951741
NCBI GeneID
12359
NCBI Accession #
NP_033934.2
UniProt Primary Accession #
P24270
UniProt Secondary Accession #
Q3TXQ6
UniProt Related Accession #
P24270
GenBank Nucleotide #
NM_009804.2
NCBI Official Full Name
catalase
NCBI Official Synonym Full Names
catalase
NCBI Official Symbol
Cat
NCBI Official Synonym Symbols
Cas1; Cs-1; Cas-1; 2210418N07
UniProt Protein Name
Catalase
Protein Family
Cat eye syndrome critical region protein
UniProt Gene Name
Cat
UniProt Synonym Gene Names
Cas-1; Cas1
UniProt Entry Name
CATA_MOUSE
NCBI Protein Information
catalase

UniProt Comments for CAT

Catalase: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family.

Protein type: Hydrolase; Endoplasmic reticulum; EC 1.11.1.6; Apoptosis; Energy Metabolism - methane; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - tryptophan

Cellular Component: peroxisomal membrane; Golgi apparatus; extracellular space; focal adhesion; intracellular membrane-bound organelle; mitochondrion; endoplasmic reticulum; lysosome; mitochondrial intermembrane space; cytosol; membrane; plasma membrane; peroxisome

Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; enzyme binding; peroxidase activity; catalase activity; metal ion binding; heme binding; oxidoreductase activity; NADP binding; aminoacylase activity; receptor binding

Biological Process: cholesterol metabolic process; hemoglobin metabolic process; protein homotetramerization; activation of NF-kappaB transcription factor; positive regulation of phosphoinositide 3-kinase cascade; osteoblast differentiation; response to reactive oxygen species; triacylglycerol metabolic process; UV protection; inhibition of NF-kappaB transcription factor; ureteric bud development; hydrogen peroxide catabolic process; positive regulation of cell division; response to hypoxia; aerobic respiration; response to oxidative stress; kidney development; protein tetramerization; negative regulation of apoptosis
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Research Articles on CAT

1. exposure to either 14- or 28-day chronic stress resulted in a depressive-like syndrome, behavioural invigoration and aggression, and decreased activity of two major brain peroxidation enzymes, superoxide dismutase and catalase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CAT sirna

 Reference Product  PubMed Publications
 Sod1 sirna  >218 publications with CAT and Sod1
 Sod2 sirna  >175 publications with CAT and Sod2
 Gsr sirna  >50 publications with CAT and Gsr
 Sod3 sirna  >30 publications with CAT and Sod3
 Xdh sirna  >10 publications with CAT and Xdh
 Prdx6 sirna  >6 publications with CAT and Prdx6

Pathways associated with CAT sirna

 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Folic Acid Network Pathway antibodies  Folic Acid Network Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram

Diseases associated with CAT sirna

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1422 publications with CAT and Necrosis
 Asthma Antibodies  >1351 publications with CAT and Asthma
 Diabetes Mellitus Antibodies  >1268 publications with CAT and Diabetes Mellitus
 Hypertension Antibodies  >876 publications with CAT and Hypertension
 Edema Antibodies  >741 publications with CAT and Edema
 Seizures Antibodies  >699 publications with CAT and Seizures
 Disease Progression Antibodies  >622 publications with CAT and Disease Progression
 Brain Ischemia Antibodies  >573 publications with CAT and Brain Ischemia
 Heart Failure Antibodies  >513 publications with CAT and Heart Failure
 Reperfusion Injury Antibodies  >476 publications with CAT and Reperfusion Injury

Organs/Tissues associated with CAT sirna

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23468 publications with CAT and Brain
 Blood Antibodies  >17029 publications with CAT and Blood
 Muscle Antibodies  >9801 publications with CAT and Muscle
 Eye Antibodies  >5941 publications with CAT and Eye
 Spinal Cord Antibodies  >5242 publications with CAT and Spinal Cord
 Liver Antibodies  >5060 publications with CAT and Liver
 Heart Antibodies  >4970 publications with CAT and Heart
 Skin Antibodies  >4395 publications with CAT and Skin
 Kidney Antibodies  >3426 publications with CAT and Kidney
 Bone Antibodies  >2951 publications with CAT and Bone
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