DAB1 siRNA – Disabled Homolog 1 Isoform 1 (Mouse)

DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons

Protein type: Adaptor/scaffold

Cellular Component: neuron projection; membrane; cell soma; apical part of cell; perinuclear region of cytoplasm; postsynaptic density; intracellular; cytosol; brush border

Molecular Function: protein binding; phosphoinositide 3-kinase binding; phospholipid binding; SH2 domain binding

Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; nervous system development; central nervous system development; Golgi localization; cerebellum structural organization; multicellular organismal development; neuron migration; negative regulation of cell adhesion; adult walking behavior; cerebral cortex cell migration; positive regulation of protein kinase activity; small GTPase mediated signal transduction; radial glia guided migration of Purkinje cell; negative regulation of astrocyte differentiation; dendrite development; negative regulation of axonogenesis; cerebral cortex radially oriented cell migration; cell differentiation; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade