ERBB3 siRNA – Receptor Tyrosine-Protein Kinase Erbb-3 (Mouse)

HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Oncoprotein; TK group; EGFR family

Cellular Component: extracellular space; postsynaptic membrane; membrane; basolateral plasma membrane; apical plasma membrane; integral to membrane; nucleus; lateral plasma membrane; receptor complex

Molecular Function: identical protein binding; nucleotide binding; protein tyrosine kinase activator activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; protein heterodimerization activity; growth factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; cranial nerve development; negative regulation of cell adhesion; signal transduction; protein amino acid phosphorylation; regulation of cell proliferation; peripheral nervous system development; negative regulation of signal transduction; Schwann cell differentiation; positive regulation of glucose import; neuron apoptosis; negative regulation of secretion; negative regulation of neuron apoptosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway