JAK2 siRNA – Tyrosine-Protein Kinase JAK2 (Mouse)

JAK2: a non-receptor tyrosine-kinase involved in a specific subset of cytokine receptor signaling pathways, including IL-3, -5 and GM-CSF. Interacts with IL23R, SKB1 and STAM2. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. Fusion of Jak2 to TEL1 (ETV6) by t(9;12)(p24;p13) causes myeloproliferative disease in humans and mouse models. The Jak inhibitor AG490 inhibits constitutive Jak2 phosphorylation and causes apoptosis in cells from breast cancer and relapsing acute lymphoblastic leukemia. A single activating mutation is associated with several hematological malignancies. Inhibitor: AG490.

Protein type: Protein kinase, TK; Oncoprotein; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; nuclear matrix; membrane; cytoplasm; caveola; intracellular; cytosol; nucleus; lipid raft

Molecular Function: protein C-terminus binding; histone binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; acetylcholine receptor binding; protein kinase binding; interleukin-12 receptor binding; protein kinase activity; transferase activity; protein binding; growth hormone receptor binding; peptide hormone receptor binding; protein-tyrosine kinase activity; insulin receptor substrate binding; transferase activity, transferring phosphorus-containing groups; heme binding; phosphoinositide 3-kinase binding; kinase activity; type 1 angiotensin receptor binding; SH2 domain binding; ATP binding; receptor binding

Biological Process: positive regulation of nitric oxide biosynthetic process; activation of MAPKK activity; positive regulation of apoptosis; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; tyrosine phosphorylation of JAK2 protein; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; response to antibiotic; elevation of cytosolic calcium ion concentration; tumor necrosis factor-mediated signaling pathway; erythrocyte differentiation; negative regulation of neuron apoptosis; positive regulation of cell activation; positive regulation of DNA binding; positive regulation of protein import into nucleus, translocation; axon regeneration; positive regulation of insulin secretion; chromatin modification; JAK-STAT cascade; positive regulation of tumor necrosis factor production; tyrosine phosphorylation of Stat5 protein; positive regulation of phosphoinositide 3-kinase cascade; tyrosine phosphorylation of STAT protein; positive regulation of peptidyl-tyrosine phosphorylation; response to hydroperoxide; mineralocorticoid receptor signaling pathway; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; response to oxidative stress; positive regulation of cell differentiation; negative regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; negative regulation of heart contraction; hormone-mediated signaling; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; signal transduction; host programmed cell death induced by symbiont; negative regulation of cell proliferation; positive regulation of cell proliferation; inflammatory response; cell differentiation; STAT protein nuclear translocation; caspase activation; regulation of cell adhesion; cell migration; immune system process; cytokine and chemokine mediated signaling pathway; negative regulation of DNA binding; G-protein coupled receptor protein signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of inflammatory response; innate immune response; myeloid cell differentiation; negative regulation of cell-cell adhesion; induction of apoptosis by oxidative stress; phosphorylation; positive regulation of cell migration; positive regulation of inflammatory response