LGR5 siRNA – Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5 (Mouse)

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]

LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; plasma membrane; integral to membrane; trans-Golgi network membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; transmembrane receptor activity; protein-hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; hair follicle development; oocyte differentiation; signal transduction; inner ear development