LHX4 siRNA – LIM/Homeobox Protein Lhx4 (Mouse)

LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.

Protein type: DNA-binding; Oncoprotein

Cellular Component: intracellular; nucleus

Molecular Function: DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding

Biological Process: organ morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; medial motor column neuron differentiation; motor axon guidance; placenta development; negative regulation of apoptosis