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RDX siRNA – Radixin Isoform a (Mouse)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8218631

MBS8218631 is an siRNA targeting RDX. Also known as RDX siRNA (Mouse). Reactive in Mouse. Host: Synthetic. siRNA to inhibit RDX expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RDX, siRNA
Full Product Name
RDX siRNA (Mouse)
Product Gene Name
RDX sirna
Product Synonym Names
Radixin; ESP10
Host
Synthetic
Species Reactivity
Mouse
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
RDX siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
68,543 Da
3D Structure
ModBase 3D Structure for P26043
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse RDX gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for RDX sirna
RNA Interference (RNAi)

Other Notes

Small volumes of RDX sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RDX. It may not necessarily be applicable to this product.

NCBI GI #
157277950
NCBI GeneID
19684
NCBI Accession #
NP_001098086.1
UniProt Primary Accession #
P26043
UniProt Secondary Accession #
Q3TS85; Q9QW27
UniProt Related Accession #
P26043
GenBank Nucleotide #
NM_001104616.1
NCBI Official Full Name
radixin isoform a
NCBI Official Synonym Full Names
radixin
NCBI Official Symbol
Rdx
NCBI Official Synonym Symbols
AA516625
UniProt Protein Name
Radixin
UniProt Synonym Protein Names
ESP10
Protein Family
Protein roadkill
UniProt Gene Name
Rdx
UniProt Entry Name
RADI_MOUSE
NCBI Protein Information
radixin

UniProt Comments for RDX

Radixin: a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Cellular Component: extracellular space; microvillus; focal adhesion; T-tubule; ruffle; stereocilium; cytoskeleton; cell-cell adherens junction; extrinsic to membrane; membrane; apical part of cell; lamellipodium; cytoplasm; plasma membrane; midbody; myelin sheath; cleavage furrow; filopodium

Molecular Function: protein binding; cytoskeletal protein binding; actin binding

Biological Process: microvillus biogenesis; apical protein localization; actin filament capping; barbed-end actin filament capping
Show more

Research Articles on RDX

1. These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RDX sirna

 Reference Product  PubMed Publications
 Actb sirna  >2 publications with RDX and Actb

Pathways associated with RDX sirna

 Products by Pathway  Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with RDX sirna

 Disease Name  Pubmed Publications
 Poisoning Antibodies  >21 publications with RDX and Poisoning
 Weight Loss Antibodies  >6 publications with RDX and Weight Loss
 Liver Diseases Antibodies  >6 publications with RDX and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with RDX and Liver Neoplasms
 Carcinoma Antibodies  >3 publications with RDX and Carcinoma
 Hypertension Antibodies  >3 publications with RDX and Hypertension
 Disease Models, Animal Antibodies  >3 publications with RDX and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >2 publications with RDX and Carcinoma, Hepatocellular
 Hepatomegaly Antibodies  >2 publications with RDX and Hepatomegaly
 Necrosis Antibodies  >2 publications with RDX and Necrosis

Organs/Tissues associated with RDX sirna

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with RDX and Blood
 Liver Antibodies  >29 publications with RDX and Liver
 Brain Antibodies  >20 publications with RDX and Brain
 Skin Antibodies  >11 publications with RDX and Skin
 Bone Antibodies  >10 publications with RDX and Bone
 Kidney Antibodies  >9 publications with RDX and Kidney
 Lung Antibodies  >7 publications with RDX and Lung
 Muscle Antibodies  >6 publications with RDX and Muscle
 Spleen Antibodies  >5 publications with RDX and Spleen
 Heart Antibodies  >5 publications with RDX and Heart
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