SLC6A4 siRNA – Sodium-Dependent Serotonin Transporter (Mouse)

SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter

Cellular Component: neuron projection; membrane; integral to plasma membrane; integral to membrane; plasma membrane; endomembrane system; cytosol; endosome; lipid raft

Molecular Function: serotonin transmembrane transporter activity; protein homodimerization activity; serotonin:sodium symporter activity; myosin binding; symporter activity; actin filament binding; protein binding; cocaine binding; syntaxin-1 binding; neurotransmitter:sodium symporter activity; monoamine transmembrane transporter activity; nitric-oxide synthase binding; Rab GTPase binding

Biological Process: circadian rhythm; vasoconstriction; response to toxin; monoamine transport; positive regulation of cell cycle; thalamus development; social behavior; serotonin uptake; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; memory; protein oligomerization; negative regulation of granule cell precursor proliferation; negative regulation of neuron differentiation; transport; neurotransmitter transport; brain morphogenesis; sperm ejaculation; serotonin transport; protein homooligomerization