SMAD3 siRNA – Mothers Against Decapentaplegic Homolog 3 (Mouse)

SMAD3: transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.

Protein type: Nuclear receptor co-regulator; Transcription factor; DNA-binding

Cellular Component: nucleoplasm; transcription factor complex; protein complex; nuclear chromatin; cytoplasm; plasma membrane; nuclear inner membrane; intracellular; nucleus; receptor complex

Molecular Function: identical protein binding; ubiquitin binding; protein homodimerization activity; zinc ion binding; chromatin DNA binding; metal ion binding; beta-catenin binding; protein kinase binding; transcription factor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; phosphatase binding; collagen binding; protein binding; enzyme binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; SMAD binding; transforming growth factor beta receptor binding; transcription factor activity

Biological Process: developmental growth; positive regulation of positive chemotaxis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; paraxial mesoderm morphogenesis; gastrulation; embryonic pattern specification; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; embryonic foregut morphogenesis; positive regulation of stress fiber formation; negative regulation of mitotic cell cycle; negative regulation of osteoblast differentiation; cell cycle arrest; regulation of striated muscle development; pericardium development; somitogenesis; transcription, DNA-dependent; embryonic cranial skeleton morphogenesis; osteoblast development; regulation of transcription from RNA polymerase II promoter; positive regulation of chondrocyte differentiation; mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast proliferation; negative regulation of protein catabolic process; endoderm development; negative regulation of apoptosis; transcription from RNA polymerase II promoter; evasion of host defenses by virus; T cell activation; negative regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell proliferation; negative regulation of cell proliferation; positive regulation of focal adhesion formation; negative regulation of protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transport; positive regulation of transforming growth factor-beta3 production; positive regulation of transcription factor import into nucleus; thyroid gland development; heart looping; skeletal development; caspase activation; intercellular junction assembly and maintenance; regulation of transforming growth factor-beta2 production; regulation of immune response; protein stabilization; regulation of binding; in utero embryonic development; positive regulation of bone mineralization; liver development; SMAD protein complex assembly; osteoblast differentiation; immune system development; positive regulation of interleukin-1 beta production; negative regulation of inflammatory response; response to hypoxia; immune response; negative regulation of cell growth; positive regulation of cell migration