STK24 siRNA – Serine/Threonine-Protein Kinase 24 (Mouse)

Name: STK24 siRNA; Serine/Threonine-Protein Kinase 24; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS8209094
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8209094

MBS8209094 is an siRNA targeting STK24. Also known as STK24 siRNA (Mouse). Reactive in Mouse. Host: Synthetic. siRNA to inhibit STK24 expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STK24, siRNA

Full Product Name

STK24 siRNA (Mouse)

Product Gene Name

STK24 sirna

Product Synonym Names

MST3; STK3; Serine/threonine-protein kinase 24; Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3

Host

Synthetic

Species Reactivity

Mouse

Form/Format

Lyophilized powder

Purity/Purification

> 97%

Specificity

STK24 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Molecular Weight

47,954 Da

3D Structure

ModBase 3D Structure for Q99KH8

Negative Control

siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.

Quality Control

Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.

Directions for Use

We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).

Components

We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse STK24 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.

Applications Tested/Suitable for STK24 sirna

RNA Interference (RNAi)

Other Notes

Small volumes of STK24 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STK24. It may not necessarily be applicable to this product.

NCBI GI #

21703922

NCBI GeneID

223255

NCBI Accession #

NP_663440.1

UniProt Primary Accession #

Q99KH8

UniProt Related Accession #

Q99KH8

GenBank Nucleotide #

NM_145465.2

NCBI Official Full Name

serine/threonine-protein kinase 24

NCBI Official Synonym Full Names

serine/threonine kinase 24

NCBI Official Symbol

Stk24

NCBI Official Synonym Symbols

Mst3; MST-3; STE20; C76483; 1810013H02Rik

UniProt Protein Name

Serine/threonine-protein kinase 24

UniProt Synonym Protein Names

Mammalian STE20-like protein kinase 3; MST-3

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

Stk24

UniProt Synonym Gene Names

Mst3; Stk3; MST-3; MST3/N; MST3/C

UniProt Entry Name

STK24_MOUSE

NCBI Protein Information

serine/threonine-protein kinase 24

UniProt Comments for STK24

MST3: a protein kinase of the STE20 family. Activated by caspase-mediated cleavage

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE20 family; YSK subfamily

Cellular Component: Golgi membrane; membrane; cytoplasm; nucleolus; nucleus

Molecular Function: transferase activity; protein serine/threonine kinase activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: regulation of axon regeneration; positive regulation of axon regeneration; response to hydrogen peroxide; apoptosis; protein amino acid autophosphorylation; regulation of cell differentiation; response to stress; induction of apoptosis by oxidative stress; phosphorylation; negative regulation of cell migration; protein amino acid phosphorylation

Research Articles on STK24

1. Mst3 phosphorylates RhoA at Ser26, thereby negatively regulating the activity of RhoA in neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STK24 sirna

Reference Product	PubMed Publications
Pdcd10 sirna	>8 publications with STK24 and Pdcd10
Strn sirna	>2 publications with STK24 and Strn
Strn3 sirna	>1 publications with STK24 and Strn3

Pathways associated with STK24 sirna

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Programmed Cell Death Pathway antibodies	Programmed Cell Death Pathway Diagram

Diseases associated with STK24 sirna

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with STK24 and Nervous System Diseases
Cardiovascular Diseases Antibodies	>5 publications with STK24 and Cardiovascular Diseases
Brain Diseases Antibodies	>3 publications with STK24 and Brain Diseases
Acute Kidney Injury Antibodies	>2 publications with STK24 and Acute Kidney Injury
Kidney Diseases Antibodies	>2 publications with STK24 and Kidney Diseases
Inflammation Antibodies	>2 publications with STK24 and Inflammation
Liver Diseases Antibodies	>1 publications with STK24 and Liver Diseases
Neurobehavioral Manifestations Antibodies	>1 publications with STK24 and Neurobehavioral Manifestations

Organs/Tissues associated with STK24 sirna

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>6 publications with STK24 and Kidney
Brain Antibodies	>5 publications with STK24 and Brain
Blood Antibodies	>3 publications with STK24 and Blood
Eye Antibodies	>3 publications with STK24 and Eye
Dorsal Root Ganglion Antibodies	>2 publications with STK24 and Dorsal Root Ganglion
Liver Antibodies	>2 publications with STK24 and Liver
Muscle Antibodies	>2 publications with STK24 and Muscle
Intestine Antibodies	>1 publications with STK24 and Intestine
Spleen Antibodies	>1 publications with STK24 and Spleen