TEAD1 siRNA – Transcriptional Enhancer Factor TEF-1 Isoform 2 (Mouse)

TEAD1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: heart development; lateral mesoderm development; notochord development; paraxial mesoderm development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transition between fast and slow fiber