TLR2 siRNA – Toll-Like Receptor 2 (Mouse)

TLR2: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family.

Protein type: Apoptosis; Cell surface; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: cell surface; cell projection; membrane; cytoplasm; plasma membrane; integral to membrane; cytoplasmic vesicle; external side of plasma membrane

Molecular Function: protein binding; peptidoglycan binding; transmembrane receptor activity; protein heterodimerization activity; triacylated lipoprotein binding; receptor activity; pattern recognition receptor activity; diacylated lipoprotein binding

Biological Process: regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; positive regulation of interleukin-12 production; positive regulation of leukocyte migration; microglial cell activation; positive regulation of NF-kappaB import into nucleus; leukotriene metabolic process; detection of triacylated bacterial lipoprotein; response to molecule of fungal origin; signal transduction; positive regulation of interleukin-18 production; nitric oxide metabolic process; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; negative regulation of cell proliferation; response to molecule of bacterial origin; response to peptidoglycan; positive regulation of interferon-beta production; response to bacterial lipoprotein; positive regulation of oligodendrocyte differentiation; inflammatory response; positive regulation of Wnt receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; negative regulation of interleukin-12 production; immune system process; detection of diacylated bacterial lipoprotein; cell surface pattern recognition receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; induction by symbiont of defense-related host nitric oxide production; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; negative regulation of interleukin-17 production; response to bacterium; myelin formation in the central nervous system; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; immune response; I-kappaB phosphorylation; chloramphenicol transport; positive regulation of inflammatory response; positive regulation of cytokine secretion; positive regulation of nitric-oxide synthase biosynthetic process