TNFSF4 siRNA – Tumor Necrosis Factor Ligand Superfamily Member 4 (Mouse)

TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.

Protein type: Cytokine; Cell cycle regulation; Membrane protein, integral

Cellular Component: extracellular space; cell surface; membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; positive regulation of activated T cell proliferation; defense response to nematode; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; T cell proliferation; positive regulation of immune effector process; regulation of adaptive immune response; positive regulation of T-helper 2 cell differentiation; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of interleukin-13 production; inflammatory response; positive regulation of memory T cell differentiation; cholesterol metabolic process; blood vessel development; positive regulation of T-helper 2 type immune response; negative regulation of transcription factor activity; response to virus; positive regulation of immunoglobulin mediated immune response; positive regulation of interleukin-6 production; cytokine production; positive regulation of immunoglobulin secretion; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; innate immune response; positive regulation of alpha-beta T cell proliferation; immune response; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response