TRIB1 siRNA – Tribbles Homolog 1 (Mouse)

TRB1: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; Trbl family

Cellular Component: cytoplasm; nucleus

Molecular Function: protein kinase inhibitor activity; mitogen-activated protein kinase kinase binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity; transferase activity, transferring phosphorus-containing groups; transcription factor binding; ATP binding; protein kinase activity

Biological Process: negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of smooth muscle cell proliferation; regulation of catalytic activity; regulation of MAP kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity; negative regulation of transcription factor activity; JNK cascade; negative regulation of protein kinase activity; response to lipopolysaccharide; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation