TRIOBP siRNA – TRIO and F-Actin-Binding Protein Isoform 4 (Mouse)

This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]

Tara: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Defects in TRIOBP are the cause of deafness autosomal recessive type 28 (DFNB28). 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding

Cellular Component: focal adhesion; cytoskeleton; cytoplasm; nucleus; actin cytoskeleton

Molecular Function: actin filament binding; ubiquitin protein ligase binding; actin binding

Biological Process: mitosis; cell division; regulation of actin cytoskeleton organization and biogenesis; cell cycle