VCP siRNA – Transitional Endoplasmic Reticulum Atpase (Mouse)

VCP: valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization.

Protein type: EC 3.6.4.6; Hydrolase; Chaperone; Endoplasmic reticulum; DNA repair, damage

Cellular Component: proteasome complex; nucleoplasm; endoplasmic reticulum membrane; protein complex; intracellular membrane-bound organelle; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; lipid particle; cytosol; nucleus; myelin sheath

Molecular Function: identical protein binding; protein domain specific binding; protein binding; hydrolase activity; ATPase activity; nucleotide binding; protein complex binding; polyubiquitin binding; ADP binding; protein phosphatase binding; lipid binding; ATP binding; receptor binding

Biological Process: ubiquitin-dependent protein catabolic process; caspase activation; ER-associated protein catabolic process; ER to Golgi vesicle-mediated transport; protein ubiquitination; DNA repair; retrograde protein transport, ER to cytosol; bypass DNA synthesis; positive regulation of protein complex assembly; transport; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; double-strand break repair; positive regulation of protein catabolic process; protein amino acid N-linked glycosylation via asparagine; response to DNA damage stimulus; protein homooligomerization