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NELF Antibody (C-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9222449

Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway.… More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NELF (NSMF), Blocking Peptide
Full Product Name
NELF Antibody (C-term) Blocking Peptide
Product Gene Name
NSMF blocking peptide
Product Synonym Gene Name
NELF
Product Synonym Names
NMDA receptor synaptonuclear signaling and neuronal migration factor; Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor; NSMF; NELF
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
NELF peptide (MBS9222449) is used for blocking the activity of NELF antibody (MBS9213635)
Molecular Weight
57,139 Da
OMIM
608137
Cellular Location
Nucleus. Nucleus envelope. Nucleus membrane Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane. Note: Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium Associates with transcriptionally active chromatin regions Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity).
Tissue Location
Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney

Other Notes

Small volumes of NSMF blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NSMF purchase

MBS9222449 is a blocking peptide targeting NSMF. Also known as NELF Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for NSMF. It may not necessarily be applicable to this product.

NCBI GI #
71152011
NCBI GeneID
26012
NCBI Accession #
Q6X4W1.1
UniProt Primary Accession #
Q6X4W1
UniProt Secondary Accession #
Q2TB96; Q6X4V7; Q6X4V8; Q6X4V9; Q8N2M2; Q96SY1; Q9NPM4; Q9NPP3; Q9NPS3
UniProt Related Accession #
Q6X4W1
NCBI Official Full Name
NMDA receptor synaptonuclear signaling and neuronal migration factor
NCBI Official Synonym Full Names
NMDA receptor synaptonuclear signaling and neuronal migration factor
NCBI Official Symbol
NSMF
NCBI Official Synonym Symbols
HH9; NELF
UniProt Protein Name
NMDA receptor synaptonuclear signaling and neuronal migration factor
UniProt Synonym Protein Names
Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
Protein Family
NMDA receptor synaptonuclear signaling and neuronal migration factor
UniProt Gene Name
NSMF
UniProt Synonym Gene Names
NELF; Nasal embryonic LHRH factor
UniProt Entry Name
NSMF_HUMAN
NCBI Protein Information
NMDA receptor synaptonuclear signaling and neuronal migration factor

NCBI Summary for NSMF

The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
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Research Articles on NSMF

1. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with NSMF blocking peptide

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1 publications with NSMF and Adenocarcinoma
 Acute Kidney Injury Antibodies  >1 publications with NSMF and Acute Kidney Injury
 Carcinoma, Hepatocellular Antibodies  >1 publications with NSMF and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with NSMF and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with NSMF and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with NSMF and Liver Neoplasms
 Idiopathic Hypogonadotropic Hypogonadism Antibodies  >1 publications with NSMF and Idiopathic Hypogonadotropic Hypogonadism
 Carcinoma Antibodies  >1 publications with NSMF and Carcinoma

Organs/Tissues associated with NSMF blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with NSMF and Eye
 Embryonic Tissue Antibodies  >2 publications with NSMF and Embryonic Tissue
 Heart Antibodies  >2 publications with NSMF and Heart
 Brain Antibodies  >2 publications with NSMF and Brain
 Uterus Antibodies  >1 publications with NSMF and Uterus
 Nerve Antibodies  >1 publications with NSMF and Nerve
 Liver Antibodies  >1 publications with NSMF and Liver
 Kidney Antibodies  >1 publications with NSMF and Kidney
 Blood Antibodies  >1 publications with NSMF and Blood
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