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SIGIRR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS223552

Rabbit anti SIGIRR (C-terminal) antibody recognises the Single Ig IL-1-related receptor (SIGIRR), a member of the Toll-like receptor-interleukin 1 receptor superfamily, defined by an intracellular Toll-IL-1R (TIR) domain. SIGIRR acts as a negative regulator… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SIGIRR, Polyclonal Antibody
Full Product Name
RABBIT ANTI SIGIRR (C-TERMINAL)
Product Gene Name
anti-SIGIRR antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
55,271 Da
OMIM
605478
Perservative Stabilisers
0.02% Sodium Azide (NaN3)
Buffer Solution
Phosphate buffered saline
Antiserum Preparation
Antiserum to SIGIRR (CT) was raised by repeated immunisation of with highly purified antigen. Purified IgG was prepared from whole serum by immunoaffinity chromatography.
Target Species
Mouse
Applications Tested/Suitable for anti-SIGIRR antibody
Immunohistology Frozen, Western Blot (WB)
Application Notes for anti-SIGIRR antibody
Western Blot: This item detects a band of approximately 43kDa in A549 cell lysate
Immunohistology - Frozen: Maximum Dilution: 10ug/ml
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1ug/ml

Testing Data #1 of anti-SIGIRR antibody

Western blot analysis of whole cell lysate from A549 human lung adenocarcinoma cells probed with Rabbit anti Mouse SIGIRR (MBS224080) at 0.5(A), 1(B) and 2(C) ug/ml
Rabbit Anti-SIGIRR Polyclonal Antibody – Cat# MBS223552

Testing Data #2 of anti-SIGIRR antibody

Immunocytochemical staining of A549 cells with Rabbit anti Mouse SIGIRR (MBS224080)
Rabbit Anti-SIGIRR Polyclonal Antibody, Testing Data #2 – Cat# MBS223552

Other Notes

Small volumes of anti-SIGIRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIGIRR purchase

MBS223552 is an antibody targeting SIGIRR. Also known as RABBIT ANTI SIGIRR (C-TERMINAL). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SIGIRR. It may not necessarily be applicable to this product.

NCBI GI #
205277449
NCBI GeneID
59307
NCBI Accession #
NP_001128525.1
UniProt Secondary Accession #
Q3KQY2; Q6UXI3; Q9H733
UniProt Related Accession #
Q6IA17
GenBank Nucleotide #
NM_001135053.1
NCBI Official Full Name
single Ig IL-1-related receptor
NCBI Official Synonym Full Names
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
NCBI Official Symbol
SIGIRR
NCBI Official Synonym Symbols
TIR8
UniProt Protein Name
Single Ig IL-1-related receptor
UniProt Synonym Protein Names
Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8
Protein Family
Single Ig IL-1-related receptor
UniProt Gene Name
SIGIRR
UniProt Synonym Gene Names
TIR8
UniProt Entry Name
SIGIR_HUMAN
NCBI Protein Information
single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; toll/interleukin-1 receptor 8

UniProt Comments for SIGIRR

SIGIRR: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription factor activity; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; signal transduction; negative regulation of chemokine biosynthetic process
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Research Articles on SIGIRR

1. Lipopolysaccharide decreases SIGIRR expression by suppressing specificity protein 1 Sp1 via the TLR4-p38 pathway in monocytes and neutrophils.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SIGIRR antibody

 Reference Product  PubMed Publications
 TLR4 antibody  >26 publications with SIGIRR and TLR4
 MYD88 antibody  >17 publications with SIGIRR and MYD88
 TOLLIP antibody  >11 publications with SIGIRR and TOLLIP
 TIRAP antibody  >8 publications with SIGIRR and TIRAP
 TLR9 antibody  >5 publications with SIGIRR and TLR9
 IRAK1 antibody  >2 publications with SIGIRR and IRAK1
 TLR5 antibody  >1 publications with SIGIRR and TLR5
 TRAF6 antibody  >1 publications with SIGIRR and TRAF6

Pathways associated with anti-SIGIRR antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
 Toll Like Receptor 2 (TLR2) Cascade Pathway antibodies  Toll Like Receptor 2 (TLR2) Cascade Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram
 Toll Like Receptor TLR1:TLR2 Cascade Pathway antibodies  Toll Like Receptor TLR1:TLR2 Cascade Pathway Diagram
 Toll Like Receptor TLR6:TLR2 Cascade Pathway antibodies  Toll Like Receptor TLR6:TLR2 Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram

Diseases associated with anti-SIGIRR antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >50 publications with SIGIRR and Inflammation
 Immune System Diseases Antibodies  >17 publications with SIGIRR and Immune System Diseases
 Necrosis Antibodies  >14 publications with SIGIRR and Necrosis
 Disease Models, Animal Antibodies  >7 publications with SIGIRR and Disease Models, Animal
 Kidney Diseases Antibodies  >6 publications with SIGIRR and Kidney Diseases
 Fibrosis Antibodies  >4 publications with SIGIRR and Fibrosis
 Nervous System Diseases Antibodies  >4 publications with SIGIRR and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with SIGIRR and Cell Transformation, Neoplastic
 Atrophy Antibodies  >2 publications with SIGIRR and Atrophy
 Heart Diseases Antibodies  >1 publications with SIGIRR and Heart Diseases

Organs/Tissues associated with anti-SIGIRR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with SIGIRR and Blood
 Lung Antibodies  >16 publications with SIGIRR and Lung
 Kidney Antibodies  >13 publications with SIGIRR and Kidney
 Intestine Antibodies  >12 publications with SIGIRR and Intestine
 Liver Antibodies  >8 publications with SIGIRR and Liver
 Brain Antibodies  >6 publications with SIGIRR and Brain
 Bone Antibodies  >3 publications with SIGIRR and Bone
 Thymus Antibodies  >2 publications with SIGIRR and Thymus
 Spleen Antibodies  >2 publications with SIGIRR and Spleen
 Eye Antibodies  >2 publications with SIGIRR and Eye
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