Rabbit Anti-TLE2 Polyclonal Antibody – Cat# MBS5316275

Western blot analysis of TLE2 expression in HeLa (A); Jurkat (B) whole cell lysates.

TLE2 Antibody – Rabbit Polyclonal

Name: TLE2 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS5316275
Price: 695 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5316275

TLE2 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. More details

$695 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TLE2, Polyclonal Antibody

Full Product Name

TLE2 Antibody

Product Gene Name

anti-TLE2 antibody

Product Synonym Names

Purified Polyclonal TLE2 Antibody; Polyclonal TLE2 antibody; Anti-TLE2 antibody; Transducin-like enhancer protein 2 antibody; Enhancer of split groucho-like protein 2 antibody; ESG2 antibody

Clonality

Polyclonal

Host

Rabbit

Form/Format

Supplied in liquid form in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3 with 30% Glycerol and 0.01% Sodium Azide

Purity/Purification

Immunogen Affinity Chromatography

Specificity

Recognizes endogenous levels of TLE2 protein

Preparation and Storage

Store at 4 degree C for short term storage. For long term, aliquot and store at -20 degree C. Avoid repeat freeze/thaw cycles.

OMIM

601041

3D Structure

ModBase 3D Structure for Q04725

Immunogen

TLE2 antibody was raised in Rabbit using a KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TLE2 as the immunogen

Product Categories/Family for anti-TLE2 antibody

DNA & RNA

Applications Tested/Suitable for anti-TLE2 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-TLE2 antibody

WB: 1:500-1:1000
IHC: 1:100-1:200

Other Notes

Small volumes of anti-TLE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLE2 purchase

MBS5316275 is an antibody targeting TLE2. Also known as TLE2 Antibody. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLE2. It may not necessarily be applicable to this product.

NCBI GI #

664806005

NCBI GeneID

7089

UniProt Primary Accession #

Q04725

UniProt Related Accession #

Q04725

GenBank Nucleotide #

NP_001287775.1

NCBI Official Full Name

transducin-like enhancer protein 2 isoform 4

NCBI Official Synonym Full Names

TLE family member 2, transcriptional corepressor

NCBI Official Symbol

TLE2

NCBI Official Synonym Symbols

ESG; ESG2; GRG2

UniProt Protein Name

Transducin-like enhancer protein 2

UniProt Synonym Protein Names

Enhancer of split groucho-like protein 2

Protein Family

Transducin-like enhancer protein

UniProt Gene Name

TLE2

UniProt Synonym Gene Names

ESG2

UniProt Entry Name

TLE2_HUMAN

NCBI Protein Information

transducin-like enhancer protein 2

UniProt Comments for TLE2

TLE2: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5. In all tissues examined, mostly in heart, brain, and muscle. Belongs to the WD repeat Groucho/TLE family.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; extracellular space; nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: Notch signaling pathway; organ morphogenesis; Wnt receptor signaling pathway; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; signal transduction

Research Articles on TLE2

1. Immunofluorescence analysis showed that TLE2 and RTA were colocalized in the same nuclear compartment in KSHV-infected cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TLE2 antibody

Products by Pathway	Pathway Diagram
Deactivation Of The Beta-catenin Transactivating Complex Pathway antibodies	Deactivation Of The Beta-catenin Transactivating Complex Pathway Diagram
Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies	Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
Formation Of The Beta-catenin:TCF Transactivating Complex Pathway antibodies	Formation Of The Beta-catenin:TCF Transactivating Complex Pathway Diagram
NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies	NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Repression Of WNT Target Genes Pathway antibodies	Repression Of WNT Target Genes Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By NOTCH Pathway antibodies	Signaling By NOTCH Pathway Diagram
Signaling By NOTCH1 Pathway antibodies	Signaling By NOTCH1 Pathway Diagram
Signaling By Wnt Pathway antibodies	Signaling By Wnt Pathway Diagram