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ADH7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645042

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols,… More details

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Product Overview

Online Datasheet in PDF
Product Name
ADH7, Polyclonal Antibody
Full Product Name
ADH7, CT (ADH7, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase)
Product Gene Name
anti-ADH7 antibody
Product Synonym Names
Anti -ADH7, CT (ADH7, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,481 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (100333418..100356667, complement). Location: 4q23-q24
OMIM
600086
3D Structure
ModBase 3D Structure for P40394
Immunogen
ADH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325~354 amino acids from the C-terminal region of human ADH7 Antibody (C-Term).

Product Categories/Family for anti-ADH7 antibody

Antibodies; Abs to Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-ADH7 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-ADH7 antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50
Immunofluorescence: 1:10-50

Western Blot (WB) of anti-ADH7 antibody

ADH7 Antibody (C-Term) western blot analysis in Jurkat,CEM,NCI-H460,K562,MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ADH7 antibody detected the ADH7 protein (arrow).
Rabbit Anti-ADH7 Polyclonal Antibody – Cat# MBS645042

Immunohistochemistry (IHC) of anti-ADH7 antibody

ADH7 Antibody (C-Term) IHC analysis in formalin fixed and paraffin embedded lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ADH7 Antibody (C-Term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ADH7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS645042

Flow Cytometry (FC/FACS) of anti-ADH7 antibody

ADH7 Antibody (C-Term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ADH7 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS645042

Immunofluorescence (IF) of anti-ADH7 antibody

Confocal immunofluorescent analysis of ADH7 Antibody (C-Term) with NCI-H460 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-ADH7 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS645042

Other Notes

Small volumes of anti-ADH7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADH7 purchase

MBS645042 is an antibody targeting ADH7. Also known as ADH7, CT (ADH7, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADH7. It may not necessarily be applicable to this product.

NCBI GI #
262073058
NCBI GeneID
131
NCBI Accession #
NP_001159976.1
UniProt Primary Accession #
P40394
UniProt Secondary Accession #
Q13713; A2RRB6; A8MVN9; B2R760; B4DWV6
UniProt Related Accession #
P40394
GenBank Nucleotide #
NM_001166504.1
NCBI Official Full Name
alcohol dehydrogenase class 4 mu/sigma chain isoform 1
NCBI Official Synonym Full Names
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Official Symbol
ADH7
NCBI Official Synonym Symbols
ADH4
UniProt Protein Name
Alcohol dehydrogenase class 4 mu/sigma chain
UniProt Synonym Protein Names
Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
ADH7
UniProt Entry Name
ADH7_HUMAN
NCBI Protein Information
alcohol dehydrogenase class 4 mu/sigma chain; retinol dehydrogenase; alcohol dehydrogenase-7; alcohol dehydrogenase VII; gastric alcohol dehydrogenase; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase; alcohol dehydrogenase class IV mu/sigma chain

NCBI Summary for ADH7

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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UniProt Comments for ADH7

ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.1; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q23-q24

Cellular Component: extracellular region; cytosol

Molecular Function: receptor antagonist activity; zinc ion binding; aldehyde oxidase activity; alcohol dehydrogenase activity; ethanol binding; alcohol dehydrogenase activity, zinc-dependent; retinol binding; retinol dehydrogenase activity

Biological Process: response to ethanol; response to bacterium; ethanol catabolic process; retinol metabolic process; xenobiotic metabolic process; retinoic acid metabolic process; ethanol oxidation; retinoid metabolic process; fatty acid omega-oxidation
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Research Articles on ADH7

1. common ADH1-7 variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADH7 antibody

 Reference Product  PubMed Publications
 ALDH2 antibody  >12 publications with ADH7 and ALDH2
 CYP2E1 antibody  >3 publications with ADH7 and CYP2E1
 ALDH3A1 antibody  >2 publications with ADH7 and ALDH3A1
 ALDH1A1 antibody  >2 publications with ADH7 and ALDH1A1
 COMT antibody  >1 publications with ADH7 and COMT

Pathways associated with anti-ADH7 antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Omega Oxidation Pathway antibodies  Fatty Acid Omega Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram

Diseases associated with anti-ADH7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with ADH7 and Neoplasms
 Carcinoma Antibodies  >4 publications with ADH7 and Carcinoma
 Esophageal Neoplasms Antibodies  >4 publications with ADH7 and Esophageal Neoplasms
 Brain Diseases Antibodies  >3 publications with ADH7 and Brain Diseases
 Heart Diseases Antibodies  >1 publications with ADH7 and Heart Diseases
 Atherosclerosis Antibodies  >1 publications with ADH7 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >1 publications with ADH7 and Cardiovascular Diseases
 Fetal Death Antibodies  >1 publications with ADH7 and Fetal Death
 Laryngeal Neoplasms Antibodies  >1 publications with ADH7 and Laryngeal Neoplasms
 Pharyngeal Neoplasms Antibodies  >1 publications with ADH7 and Pharyngeal Neoplasms

Organs/Tissues associated with anti-ADH7 antibody

 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >13 publications with ADH7 and Stomach
 Esophagus Antibodies  >3 publications with ADH7 and Esophagus
 Larynx Antibodies  >1 publications with ADH7 and Larynx
 Lung Antibodies  >1 publications with ADH7 and Lung
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